Diagnostic utility of CYFRA 21-1 and CEA assays in pericardial fluid for the recognition of neoplastic pericarditis

A positive cytology result in pericardial fluid is the gold standard for recognition of malignant pericardial effusion. Unfortunately, in 30-50% of patients with malignant pericardial effusion cytological examination of the pericardial fluid is negative. Tumor marker assessment in pericardial fluid...

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Bibliographic Details
Published in:The International journal of biological markers 2005, Vol.20 (1), p.43-49
Main Authors: SZTURMOWICZ, M, TOMKOWSKI, W, FIJALKOWSKA, A, KUPIS, W, CIESLIK, A, DEMKOW, U, LANGFORT, R, WIECHECKA, A, ORLOWSKI, T, TORBICKI, A
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Analytical, structural and metabolic biochemistry
Antigens, Neoplasm - analysis
Biological and medical sciences
Biomarkers, Tumor - analysis
Body Fluids - chemistry
Carcinoembryonic Antigen - analysis
Female
Fundamental and applied biological sciences. Psychology
Heart Neoplasms - complications
Heart Neoplasms - diagnosis
Heart Neoplasms - metabolism
Heart Neoplasms - pathology
Humans
Investigative techniques, diagnostic techniques (general aspects)
Keratin-19
Keratins
Male
Medical sciences
Middle Aged
Pericarditis - complications
Pericarditis - diagnosis
Pericarditis - metabolism
Pericarditis - pathology
Pericardium - chemistry
ROC Curve
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Summary:A positive cytology result in pericardial fluid is the gold standard for recognition of malignant pericardial effusion. Unfortunately, in 30-50% of patients with malignant pericardial effusion cytological examination of the pericardial fluid is negative. Tumor marker assessment in pericardial fluid may help to recognize malignant pericardial effusion. The aim of our study was to estimate the value of CYFRA 21-1 and CEA measurement in pericardial fluid for the recognition of malignant pericardial effusion. To our knowledge this is the first study on CYFRA 21-1 assessment in pericardial effusion. The examined group consisted of 50 patients with malignant pericardial effusion and 34 patients with non-malignant pericardial effusion. Median CEA concentrations in malignant pericardial effusion and non-malignant pericardial effusion were 80 ng/mL (0-317) and 0.5 ng/mL (0-18.4), respectively (p5 ng/mL were found in 14/15 patients with malignant pericardial effusion and negative pericardial fluid cytology. We therefore strongly recommend the use of CYFRA 21-1 and/or CEA in addition to pericardial fluid cytology for the recognition of malignant pericardial effusion.
ISSN:0393-6155
1724-6008
1724-6008
DOI:10.1177/172460080502000107