Unilateral low-frequency stimulation of central piriform cortex delays seizure development induced by amygdaloid kindling in rats

Low-frequency stimulation of the kindling site interferes with the course of kindling epileptogenesis. The present study examined the effect of unilateral low-frequency stimulation of the central piriform cortex on seizure development induced by amygdaloid kindling in rats. The ipsilateral or contra...

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Bibliographic Details
Published in:Neuroscience 2006, Vol.138 (4), p.1089-1096
Main Authors: Yang, L.-X., Jin, C.-L., Zhu-Ge, Z.-B., Wang, S., Wei, E.-Q., Bruce, I.C., Chen, Z.
Format: Article
Language:English
Subjects:
Amygdala - physiopathology
Animals
Biological and medical sciences
Disease Models, Animal
Electric Stimulation Therapy - methods
epilepsy
Epilepsy - physiopathology
Epilepsy - therapy
focal seizure
Functional Laterality - physiology
Fundamental and applied biological sciences. Psychology
generalized seizure
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Kindling, Neurologic - physiology
long-term depression
Long-Term Synaptic Depression - physiology
Male
Medical sciences
Nervous system (semeiology, syndromes)
Neural Inhibition - physiology
Neural Pathways - physiopathology
Neurology
Olfactory Pathways - physiology
Rats
Rats, Sprague-Dawley
Time Factors
Treatment Outcome
Vertebrates: nervous system and sense organs
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Summary:Low-frequency stimulation of the kindling site interferes with the course of kindling epileptogenesis. The present study examined the effect of unilateral low-frequency stimulation of the central piriform cortex on seizure development induced by amygdaloid kindling in rats. The ipsilateral or contralateral central piriform cortex received low-frequency stimulation (15 min train of 0.1 ms pulses at 1Hz and 50–150 μA) immediately after termination of once daily kindling stimulation (2 s train of 1 ms pulses at 60Hz and 150–300 μA) in the right amygdala for 30 days. Low-frequency stimulation of either the ipsilateral or contralateral central piriform cortex significantly suppressed the progression of seizure stages and reduced afterdischarge duration throughout the course of amygdaloid kindling. The marked suppression induced by low-frequency stimulation of the central piriform cortex on either side was predominantly due to the significant retardation of progression from stage 0 to stage 1 and stage 3 to stage 4 seizures. In addition, the suppressive effect of low-frequency stimulation did not disappear when the stimulation was stopped; it could persist for at least 10 days. These findings indicate that brain areas other than the kindling focus, such as the central piriform cortex on both sides, can also be used as reasonable targets for low-frequency stimulation to retard seizure development induced by amygdaloid kindling. Secondly, like the ipsilateral central piriform cortex, the contralateral central piriform cortex may also participate in the progression and secondary generalization of focal seizures. The study suggests that unilateral low-frequency stimulation of the central piriform cortex may have a significant antiepileptogenic effect, and may be helpful for exploring effective and long-lasting therapies for human temporal lobe epilepsy.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2005.12.006