Biphasic solitary fibrous tumour : a report of two cases with epithelioid features

We present two cases of solitary fibrous tumour (SFT) showing biphasic morphology with a spectrum of malignant epithelioid components. Slides prepared from formalin-fixed and paraffin-embedded tissue from both cases were stained with haematoxylin and eosin and by immunohistochemistry. Interphase flu...

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Bibliographic Details
Published in:Virchows Archiv : an international journal of pathology 2006-03, Vol.448 (3), p.306-310
Main Authors: AWASTHI, R, O'NEILL, J. K, KEEN, C. E, SARSFIELD, P. T. L, DEVARAJ, V. S, STONE, C. A, SMITH, M. E. F
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomarkers, Tumor - analysis
Cell Transformation, Neoplastic
Diagnosis, Differential
DNA, Neoplasm - analysis
Epithelioid Cells - chemistry
Epithelioid Cells - pathology
Female
Humans
In Situ Hybridization, Fluorescence
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Sarcoma, Synovial - diagnosis
Soft Tissue Neoplasms - chemistry
Soft Tissue Neoplasms - pathology
Soft Tissue Neoplasms - surgery
Solitary Fibrous Tumors - chemistry
Solitary Fibrous Tumors - pathology
Solitary Fibrous Tumors - surgery
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Summary:We present two cases of solitary fibrous tumour (SFT) showing biphasic morphology with a spectrum of malignant epithelioid components. Slides prepared from formalin-fixed and paraffin-embedded tissue from both cases were stained with haematoxylin and eosin and by immunohistochemistry. Interphase fluorescent in situ hybridisation studies were performed in both cases using paraffin-embedded tissue to look for the t(X;18) translocation, thereby to exclude synovial sarcoma. Both cases showed biphasic morphology with some areas having typical benign spindled SFT morphology (including CD34 expression) and other areas having a malignant epithelioid appearance. In one of the cases, the epithelioid area, which was well circumscribed and showed packeting of cell groups, demonstrated expression of cytokeratin and epithelial cadherin but not of CD34. In the second case, the immunophenotype of the epithelioid component was similar to that of the benign SFT component. These findings suggest that epithelioid change in SFT shows a range of differentiation at one end, similar to that of a standard SFT, and at the other end, possibly acquiring epithelial characteristics.
ISSN:0945-6317
1432-2307
DOI:10.1007/s00428-005-0099-8