Copper(I)-Only Catalyzed Reactions of (E)-2,3-Difluoro-3-stannylacrylic Ester with Acid Chlorides and Mechanistic Studies of the “Copper Effect” in Stille Coupling Reactions

The reactions of (E)-2,3-difluoro-3-stannylacrylic ester with acid chlorides under catalysis of CuI stereospecifically afforded ethyl (2Z)-2,3-difluoro-4-oxo-substituted 2-butenoates in good yields. Moreover, direct spectroscopic observation of the corresponding organocopper reagent was observed for...

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Bibliographic Details
Published in:Organic letters 2006-03, Vol.8 (6), p.1109-1111
Main Authors: Wang, Yi, Burton, Donald J
Format: Article
Language:English
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Summary:The reactions of (E)-2,3-difluoro-3-stannylacrylic ester with acid chlorides under catalysis of CuI stereospecifically afforded ethyl (2Z)-2,3-difluoro-4-oxo-substituted 2-butenoates in good yields. Moreover, direct spectroscopic observation of the corresponding organocopper reagent was observed for the first time in Stille coupling reactions of organostannanes.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol053023x