Evaluation of Serum Levels of Interleukin (IL)–6, IL-10, and Tumor Necrosis Factor–α in Patients with Crimean-Congo Hemorrhagic Fever

We investigated the role played by cytokines in the mortality of patients with Crimean-Congo hemorrhagic fever (CCHF). Serum levels of several cytokines were measured in 3 patients with fatal CCHF and in 27 patients with nonfatal CCHF. Levels of interleukin (IL)–6 (P⩽.001) and tumor necrosis factor...

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Bibliographic Details
Published in:The Journal of infectious diseases 2006-04, Vol.193 (7), p.941-944
Main Authors: Ergonul, Onder, Tuncbilek, Semra, Baykam, Nurcan, Celikbas, Aysel, Dokuzoguz, Basak
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Coagulation
Crimean Congo hemorrhagic fever virus
Cytokines
Disseminated Intravascular Coagulation
Ebola virus
Female
Fundamental and applied biological sciences. Psychology
Hemorrhagic Fever, Crimean - immunology
Hemorrhagic Fever, Crimean - mortality
Humans
Infections
Infectious diseases
Interleukin-10 - blood
Interleukin-6 - blood
Interleukins
Male
Medical sciences
Microbiology
Middle Aged
Mortality
Platelets
Statistics as Topic
Tumor Necrosis Factor-alpha - analysis
Viruses
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Summary:We investigated the role played by cytokines in the mortality of patients with Crimean-Congo hemorrhagic fever (CCHF). Serum levels of several cytokines were measured in 3 patients with fatal CCHF and in 27 patients with nonfatal CCHF. Levels of interleukin (IL)–6 (P⩽.001) and tumor necrosis factor (TNF)–α (P=.004) were significantly higher in patients with fatal CCHF than in patients with nonfatal CCHF, whereas levels of IL-10 were not significantly different between the 2 groups (P=.937). Disseminated intravascular coagulation (DIC) scores were also higher in the patients with fatal CCHF (P=.023). Levels of IL-6 and TNF-α were positively correlated with DIC scores, whereas levels of IL-10 were negatively correlated with DIC scores. In conclusion, these findings demonstrate that proinflammatory cytokines play a major role in the mortality of patients with CCHF
ISSN:0022-1899
1537-6613
DOI:10.1086/500836