Some physical and microstructural properties of genipin-crosslinked gelatin–maltodextrin hydrogels

The physical properties and microstructure of gelatin–maltodextrin hydrogels fixed with genipin (GP) were investigated as a function of pH (3–7), maltodextrin (MD) (0–9%, w/w) and GP (0–10 mM levels), at a constant gelatin (G) concentration (10%, w/w). Network strength (elastic modulus, E) and swell...

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Bibliographic Details
Published in:International journal of biological macromolecules 2006-02, Vol.38 (1), p.40-44
Main Authors: Nickerson, M.T., Farnworth, R., Wagar, E., Hodge, S.M., Rousseau, D., Paulson, A.T.
Format: Article
Language:English
Subjects:
Animals
Chemical Phenomena
Chemistry, Physical
Gelatin
Gelatin - chemistry
Genipin
Hydrogels
In Vitro Techniques
Iridoid Glycosides
Iridoids
Maltodextrin
Microscopy, Confocal
Molecular Structure
Phase separation
Polysaccharides - chemistry
Pyrans - chemistry
Swine
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Summary:The physical properties and microstructure of gelatin–maltodextrin hydrogels fixed with genipin (GP) were investigated as a function of pH (3–7), maltodextrin (MD) (0–9%, w/w) and GP (0–10 mM levels), at a constant gelatin (G) concentration (10%, w/w). Network strength (elastic modulus, E) and swelling behavior were characterized by large deformation testing and by swelling index (SI). In general, network strength increased and swelling decreased at higher pH, MD and GP levels, except at pH 3, where E was independent of the GP concentration until ∼7.5 mM, above which it declined. Confocal scanning laser microscopy (CLSM) images showed phase separation to be suppressed at pH 3, whereas at pH 7, separation into a self-similar dispersed phase was apparent. Overall, the judicious use of GP to crosslink G was an appropriate means of kinetically trapping MD within the gelatin network.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2005.12.017