Prevalence of myocardial infarction is related to hyperhomocysteinemia but not influenced by C677T methylenetetrahydrofolate reductase and A2756G methionine synthase polymorphisms in diabetic and non-diabetic subjects

Hyperhomocysteinemia has emerged as a novel risk factor for myocardial infarction (MI). Some mechanisms proposed to explain its relationship with coronary events are also shared by major coronary risk factors. We examined whether C677T methylenetetrahydrofolate reductase and A2756G methionine syntha...

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Published in:Clinica chimica acta 2005-05, Vol.355 (1), p.165-172
Main Authors: Helfenstein, Tatiana, Fonseca, Francisco A.H., Relvas, Waldir G.M., Santos, Andreza O., Dabela, Maria L., Matheus, Simone C.P., D'Almeida, Vânia, Tufik, Sérgio, Souza, Fernanda G., Rodrigues, Paula R., Taglieri, Rosely, Sousa, Éder F., Izar, Maria C.O.
Format: Article
Language:English
Subjects:
5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - genetics
Adult
Aged
Case-Control Studies
Diabetes mellitus
Diabetes Mellitus, Type 2 - complications
Female
Homocysteine
Homocysteine - blood
Humans
Hyperhomocysteinemia - complications
Male
Methionine synthase
Methylenetetrahydrofolate reductase
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
Middle Aged
Myocardial infarction
Myocardial Infarction - epidemiology
Myocardial Infarction - etiology
Myocardial Infarction - genetics
Polymorphism, Single Nucleotide
Polymorphisms
Regression Analysis
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Summary:Hyperhomocysteinemia has emerged as a novel risk factor for myocardial infarction (MI). Some mechanisms proposed to explain its relationship with coronary events are also shared by major coronary risk factors. We examined whether C677T methylenetetrahydrofolate reductase and A2756G methionine synthase polymorphisms could affect the relative risk for MI. A sample of 196 individuals was divided into four groups (diabetics with MI, n=43; diabetics without MI, n=50; non-diabetics with MI, n=47; non-diabetics without MI, n=56) and compared regarding the prevalence of the polymorphisms, risk factors, and biochemical parameters. Higher prevalence of hyperhomocysteinemia was found in MI patients ( p
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cccn.2004.12.002