Age and sex variability and normal reference values for the V(MCA)/V(ICA) index

The index of mean blood flow velocity (V) in the middle cerebral artery (MCA) divided by respective velocity in the ipsilateral internal carotid artery (ICA), or V(MCA)/V(ICA) index, is commonly used as a marker of vasospasm, although reference values are not established. We sought to provide refere...

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Bibliographic Details
Published in:American journal of neuroradiology : AJNR 2005-04, Vol.26 (4), p.730-735
Main Authors: Krejza, Jaroslaw, Szydlik, Piotr, Liebeskind, David S, Kochanowicz, Jan, Bronov, Oleg, Mariak, Zenon, Melhem, Elias R
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Blood Flow Velocity
Carotid Arteries - diagnostic imaging
Carotid Arteries - physiology
Cerebral Arteries - diagnostic imaging
Cerebral Arteries - physiology
Female
Humans
Male
Middle Aged
Reference Values
Sex Factors
Ultrasonography, Doppler, Transcranial
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Summary:The index of mean blood flow velocity (V) in the middle cerebral artery (MCA) divided by respective velocity in the ipsilateral internal carotid artery (ICA), or V(MCA)/V(ICA) index, is commonly used as a marker of vasospasm, although reference values are not established. We sought to provide reference data for these velocities and index. Transcranial color-coded duplex and carotid duplex sonography was performed in 335 healthy volunteers (211 women, 124 men; mean age +/- SD, 42 +/- 18 years; range, 18-86 years). Age analyses were based on three groups: I, 60 years. The V(MCA)/V(ICA) index was calculated based on angle-corrected blood flow velocities determined in the MCA and extracranial ICA. Mean flow velocities in the MCA and ICA diminished with increasing age, most pronounced in those subjects >40 years. The V(MCA)/V(ICA) index increased significantly (1.67 + 0.005 [age]; P < .05) with age in women, but not in men. In women, reference values and ranges for the V(MCA)/V(ICA) index were as follows, by group: I, 1.82 (range, 0.88-2.68); II, 1.91 (range, 0.94-2.88); and III, 2.06 (range, 0.59-3.53). Respective values for men were as follows, by group: I, 2.10 (range, 0.96-3.24); II, 2.04 (range, 0.71-3.37); and III, 1.78 (range, 0.81-2.75). In subjects
ISSN:0195-6108
1936-959X