Acute phase HBV-specific T cell responses associated with HBV persistence after HBV/HCV coinfection

To characterize acute-phase hepatitis B virus (HBV)-specific T cell responses associated with self-limited and persistent HBV infections, we compared a patient with acute HBV/HCV coinfection, who was able to control HCV but developed chronic hepatitis B, with patients who resolved acute HBV infectio...

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Bibliographic Details
Published in:Hepatology (Baltimore, Md.) Md.), 2005-04, Vol.41 (4), p.826-831
Main Authors: URBANI, Simona, BONI, Carolina, AMADEI, Barbara, FISICARO, Paola, CERIONI, Simona, VALLI, Maria Antonietta, MISSALE, Gabriele, FERRARI, Carlo
Format: Article
Language:English
Subjects:
Acute-Phase Reaction - immunology
Antibody Formation
Biological and medical sciences
Case-Control Studies
CD4-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - immunology
Disease Progression
Epitopes - immunology
Fundamental and applied biological sciences. Psychology
Hepatitis B - complications
Hepatitis B - immunology
Hepatitis B - physiopathology
Hepatitis B - virology
Hepatitis B Antibodies - biosynthesis
Hepatitis B Core Antigens - immunology
Hepatitis B Surface Antigens - blood
Hepatitis B virus - immunology
Hepatitis B virus - isolation & purification
Hepatitis B, Chronic - etiology
Hepatitis B, Chronic - immunology
Hepatitis C - complications
HLA-A2 Antigen - blood
HLA-A2 Antigen - immunology
Human viral diseases
Humans
Immunity, Cellular
Infectious diseases
Liver. Bile. Biliary tracts
Medical sciences
T-Lymphocytes - immunology
Vertebrates: digestive system
Viral diseases
Viral diseases of the digestive system
Viral hepatitis
Viral Load
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Summary:To characterize acute-phase hepatitis B virus (HBV)-specific T cell responses associated with self-limited and persistent HBV infections, we compared a patient with acute HBV/HCV coinfection, who was able to control HCV but developed chronic hepatitis B, with patients who resolved acute HBV infection spontaneously. Acute-phase CD4 responses were efficient in self-limited infections but undetectable in the coinfected patient with HBV persistence. CD8 responses were multispecific irrespective of the outcome of infection, but the CD8 repertoire associated with HBV persistence lacked the most dominant specificities detectable in self-limited infections. In conclusion, insufficient CD4 help and defective CD8 repertoire may play a role at the early stages of infection in influencing HBV persistence.
ISSN:0270-9139
1527-3350
DOI:10.1002/hep.20614