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Antimicrobial susceptibilities of potential bacterial pathogens in adults with acute respiratory tract infections : Prospective epidemiological network investigating community-acquired infection surveillance in nagasaki (PENICILLIN) study
The prevalence and the antimicrobial susceptibilities of bacterial pathogens in acute upper respiratory tract infections (AURTIs) is not clear. We conducted a prospective community-based multicenter study in 45 centers across Nagasaki, Japan, between December 2001 and April 2002. We examined the nas...
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| Published in: | Diagnostic microbiology and infectious disease 2005-04, Vol.51 (4), p.271-280 |
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| container_end_page | 280 |
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| container_start_page | 271 |
| container_title | Diagnostic microbiology and infectious disease |
| container_volume | 51 |
| creator | HIRAKATA, Yoichi YANAGIHARA, Katsunori MIYAZAKI, Yoshitsugu TOMONO, Kazunori KOBAYASHI, Intetsu KOHNO, Shigeru |
| description | The prevalence and the antimicrobial susceptibilities of bacterial pathogens in acute upper respiratory tract infections (AURTIs) is not clear. We conducted a prospective community-based multicenter study in 45 centers across Nagasaki, Japan, between December 2001 and April 2002. We examined the nasopharyngeal or throat isolates in 930 adult outpatients with AURTIs. Potential bacterial pathogens, including Streptococcus pyogenes (from 6.8% patients), S. pneumoniae (5.3%), S. milleri group (2.0%), Staphylococcus aureus (26.0%), Moraxella catarrhalis (7.4%), Haemophilus influenzae (17.6%), and Klebsiella pneumoniae (1.2%), were isolated from 51.8% of the patients. Penicillin nonsusceptible phenotype accounted for 44.9% of S. pneumoniae isolates. Among Staphylococcus aureus isolates, 9.1% were methicillin-resistant. In H. influenzae isolates, 6.7% produced beta-lactamase and 23.2% were beta-lactamase-negative ampicillin-resistant. The results indicated that the potential bacterial pathogens were detected in the remarkable population of the adults with AURTIs and the current antimicrobial susceptibilities of such pathogens. |
| doi_str_mv | 10.1016/j.diagmicrobio.2004.11.008 |
| format | article |
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We conducted a prospective community-based multicenter study in 45 centers across Nagasaki, Japan, between December 2001 and April 2002. We examined the nasopharyngeal or throat isolates in 930 adult outpatients with AURTIs. Potential bacterial pathogens, including Streptococcus pyogenes (from 6.8% patients), S. pneumoniae (5.3%), S. milleri group (2.0%), Staphylococcus aureus (26.0%), Moraxella catarrhalis (7.4%), Haemophilus influenzae (17.6%), and Klebsiella pneumoniae (1.2%), were isolated from 51.8% of the patients. Penicillin nonsusceptible phenotype accounted for 44.9% of S. pneumoniae isolates. Among Staphylococcus aureus isolates, 9.1% were methicillin-resistant. In H. influenzae isolates, 6.7% produced beta-lactamase and 23.2% were beta-lactamase-negative ampicillin-resistant. 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We conducted a prospective community-based multicenter study in 45 centers across Nagasaki, Japan, between December 2001 and April 2002. We examined the nasopharyngeal or throat isolates in 930 adult outpatients with AURTIs. Potential bacterial pathogens, including Streptococcus pyogenes (from 6.8% patients), S. pneumoniae (5.3%), S. milleri group (2.0%), Staphylococcus aureus (26.0%), Moraxella catarrhalis (7.4%), Haemophilus influenzae (17.6%), and Klebsiella pneumoniae (1.2%), were isolated from 51.8% of the patients. Penicillin nonsusceptible phenotype accounted for 44.9% of S. pneumoniae isolates. Among Staphylococcus aureus isolates, 9.1% were methicillin-resistant. In H. influenzae isolates, 6.7% produced beta-lactamase and 23.2% were beta-lactamase-negative ampicillin-resistant. The results indicated that the potential bacterial pathogens were detected in the remarkable population of the adults with AURTIs and the current antimicrobial susceptibilities of such pathogens.</description><subject>Acute Disease</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Community-Acquired Infections - epidemiology</subject><subject>Community-Acquired Infections - microbiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gram-Negative Bacteria - drug effects</subject><subject>Gram-Positive Cocci - drug effects</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Japan - epidemiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Penicillin Resistance</subject><subject>Penicillins - pharmacology</subject><subject>Population Surveillance</subject><subject>Prevalence</subject><subject>Prospective Studies</subject><subject>Respiratory Tract Infections - epidemiology</subject><subject>Respiratory Tract Infections - microbiology</subject><issn>0732-8893</issn><issn>1879-0070</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqFkU9v1DAQxSMEoqXwFZCFBIJDlrHzxwm3alVgpVXpAc6riTNJp03i1Ha22i_NZ8ArFvXIyWP5956e3yTJOwkrCbL8fLdqGfuRjbMN25UCyFdSrgCqZ8m5rHSdAmh4npyDzlRaVXV2lrzy_g5AqjqHl8mZLCqoMlmfJ78vp8AnKxyEX7yhOXDDAwcmL2wnZhsoQvG1QRPIHacZw63tafKCJ4HtMgQvHjncCjRLIOHIz-wwWHcQwUVVxDoygW1UfBE3zvr5eN2ToJlbGtkOtmcTnScKj9bdR8GefOAeA0-9MHYcl4nDIUXzsLCj9skxhnZ74mHAydAxz4Q9erxn8fHm6nqz3my3m-tPwoelPbxOXnQ4eHpzOi-SX1-vfq6_p9sf3zbry206Kw0hlV0LqDuUXZ1pjQq6XEHbqKaWhjDTVVE2qgClyGhTFJKKusoQulq2WuYlZRfJh7--s7MPS_zIbuTY7DEj2cXvSq0hU1X5X1DqslSqriP49gQuzUjtbnY8ojvs_q0yAu9PAPpYZOdiHeyfuFIrCXme_QFsCrnX</recordid><startdate>20050401</startdate><enddate>20050401</enddate><creator>HIRAKATA, Yoichi</creator><creator>YANAGIHARA, Katsunori</creator><creator>MIYAZAKI, Yoshitsugu</creator><creator>TOMONO, Kazunori</creator><creator>KOBAYASHI, Intetsu</creator><creator>KOHNO, Shigeru</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20050401</creationdate><title>Antimicrobial susceptibilities of potential bacterial pathogens in adults with acute respiratory tract infections : Prospective epidemiological network investigating community-acquired infection surveillance in nagasaki (PENICILLIN) study</title><author>HIRAKATA, Yoichi ; YANAGIHARA, Katsunori ; MIYAZAKI, Yoshitsugu ; TOMONO, Kazunori ; KOBAYASHI, Intetsu ; KOHNO, Shigeru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p270t-1fd0a7fa1f9377a20f420db2b91cea37856b25022ec7c551e5983a0f91d7146e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Acute Disease</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Community-Acquired Infections - epidemiology</topic><topic>Community-Acquired Infections - microbiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gram-Negative Bacteria - drug effects</topic><topic>Gram-Positive Cocci - drug effects</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Japan - epidemiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Penicillin Resistance</topic><topic>Penicillins - pharmacology</topic><topic>Population Surveillance</topic><topic>Prevalence</topic><topic>Prospective Studies</topic><topic>Respiratory Tract Infections - epidemiology</topic><topic>Respiratory Tract Infections - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HIRAKATA, Yoichi</creatorcontrib><creatorcontrib>YANAGIHARA, Katsunori</creatorcontrib><creatorcontrib>MIYAZAKI, Yoshitsugu</creatorcontrib><creatorcontrib>TOMONO, Kazunori</creatorcontrib><creatorcontrib>KOBAYASHI, Intetsu</creatorcontrib><creatorcontrib>KOHNO, Shigeru</creatorcontrib><creatorcontrib>PENICILLIN Study Group</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Diagnostic microbiology and infectious disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HIRAKATA, Yoichi</au><au>YANAGIHARA, Katsunori</au><au>MIYAZAKI, Yoshitsugu</au><au>TOMONO, Kazunori</au><au>KOBAYASHI, Intetsu</au><au>KOHNO, Shigeru</au><aucorp>PENICILLIN Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antimicrobial susceptibilities of potential bacterial pathogens in adults with acute respiratory tract infections : Prospective epidemiological network investigating community-acquired infection surveillance in nagasaki (PENICILLIN) study</atitle><jtitle>Diagnostic microbiology and infectious disease</jtitle><addtitle>Diagn Microbiol Infect Dis</addtitle><date>2005-04-01</date><risdate>2005</risdate><volume>51</volume><issue>4</issue><spage>271</spage><epage>280</epage><pages>271-280</pages><issn>0732-8893</issn><eissn>1879-0070</eissn><coden>DMIDDZ</coden><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-1</notes><notes>content type line 23</notes><notes>ObjectType-Article-1</notes><notes>ObjectType-Feature-2</notes><abstract>The prevalence and the antimicrobial susceptibilities of bacterial pathogens in acute upper respiratory tract infections (AURTIs) is not clear. We conducted a prospective community-based multicenter study in 45 centers across Nagasaki, Japan, between December 2001 and April 2002. We examined the nasopharyngeal or throat isolates in 930 adult outpatients with AURTIs. Potential bacterial pathogens, including Streptococcus pyogenes (from 6.8% patients), S. pneumoniae (5.3%), S. milleri group (2.0%), Staphylococcus aureus (26.0%), Moraxella catarrhalis (7.4%), Haemophilus influenzae (17.6%), and Klebsiella pneumoniae (1.2%), were isolated from 51.8% of the patients. Penicillin nonsusceptible phenotype accounted for 44.9% of S. pneumoniae isolates. Among Staphylococcus aureus isolates, 9.1% were methicillin-resistant. In H. influenzae isolates, 6.7% produced beta-lactamase and 23.2% were beta-lactamase-negative ampicillin-resistant. The results indicated that the potential bacterial pathogens were detected in the remarkable population of the adults with AURTIs and the current antimicrobial susceptibilities of such pathogens.</abstract><cop>New York, NY</cop><pub>Elsevier</pub><pmid>15808319</pmid><doi>10.1016/j.diagmicrobio.2004.11.008</doi><tpages>10</tpages></addata></record> |
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| identifier | ISSN: 0732-8893 |
| ispartof | Diagnostic microbiology and infectious disease, 2005-04, Vol.51 (4), p.271-280 |
| issn | 0732-8893 1879-0070 |
| language | eng |
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| source | ScienceDirect Journals |
| subjects | Acute Disease Adult Aged Aged, 80 and over Anti-Bacterial Agents - pharmacology Bacteriology Biological and medical sciences Community-Acquired Infections - epidemiology Community-Acquired Infections - microbiology Female Fundamental and applied biological sciences. Psychology Gram-Negative Bacteria - drug effects Gram-Positive Cocci - drug effects Humans Infectious diseases Japan - epidemiology Male Medical sciences Microbial Sensitivity Tests Microbiology Middle Aged Miscellaneous Penicillin Resistance Penicillins - pharmacology Population Surveillance Prevalence Prospective Studies Respiratory Tract Infections - epidemiology Respiratory Tract Infections - microbiology |
| title | Antimicrobial susceptibilities of potential bacterial pathogens in adults with acute respiratory tract infections : Prospective epidemiological network investigating community-acquired infection surveillance in nagasaki (PENICILLIN) study |
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