Antimicrobial susceptibilities of potential bacterial pathogens in adults with acute respiratory tract infections : Prospective epidemiological network investigating community-acquired infection surveillance in nagasaki (PENICILLIN) study

The prevalence and the antimicrobial susceptibilities of bacterial pathogens in acute upper respiratory tract infections (AURTIs) is not clear. We conducted a prospective community-based multicenter study in 45 centers across Nagasaki, Japan, between December 2001 and April 2002. We examined the nas...

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Bibliographic Details
Published in:Diagnostic microbiology and infectious disease 2005-04, Vol.51 (4), p.271-280
Main Authors: HIRAKATA, Yoichi, YANAGIHARA, Katsunori, MIYAZAKI, Yoshitsugu, TOMONO, Kazunori, KOBAYASHI, Intetsu, KOHNO, Shigeru
Format: Article
Language:English
Subjects:
Acute Disease
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents - pharmacology
Bacteriology
Biological and medical sciences
Community-Acquired Infections - epidemiology
Community-Acquired Infections - microbiology
Female
Fundamental and applied biological sciences. Psychology
Gram-Negative Bacteria - drug effects
Gram-Positive Cocci - drug effects
Humans
Infectious diseases
Japan - epidemiology
Male
Medical sciences
Microbial Sensitivity Tests
Microbiology
Middle Aged
Miscellaneous
Penicillin Resistance
Penicillins - pharmacology
Population Surveillance
Prevalence
Prospective Studies
Respiratory Tract Infections - epidemiology
Respiratory Tract Infections - microbiology
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Summary:The prevalence and the antimicrobial susceptibilities of bacterial pathogens in acute upper respiratory tract infections (AURTIs) is not clear. We conducted a prospective community-based multicenter study in 45 centers across Nagasaki, Japan, between December 2001 and April 2002. We examined the nasopharyngeal or throat isolates in 930 adult outpatients with AURTIs. Potential bacterial pathogens, including Streptococcus pyogenes (from 6.8% patients), S. pneumoniae (5.3%), S. milleri group (2.0%), Staphylococcus aureus (26.0%), Moraxella catarrhalis (7.4%), Haemophilus influenzae (17.6%), and Klebsiella pneumoniae (1.2%), were isolated from 51.8% of the patients. Penicillin nonsusceptible phenotype accounted for 44.9% of S. pneumoniae isolates. Among Staphylococcus aureus isolates, 9.1% were methicillin-resistant. In H. influenzae isolates, 6.7% produced beta-lactamase and 23.2% were beta-lactamase-negative ampicillin-resistant. The results indicated that the potential bacterial pathogens were detected in the remarkable population of the adults with AURTIs and the current antimicrobial susceptibilities of such pathogens.
ISSN:0732-8893
1879-0070
DOI:10.1016/j.diagmicrobio.2004.11.008