Neuropsychiatric disturbances in SLE are associated with antibodies against NMDA receptors

To determine whether neuropsychiatric manifestations in patients with systemic lupus erythematosus (SLE) are influenced by antibodies against the human N‐methyl‐d‐aspartate (NMDA) receptor types NR2a or NR2b. A decapeptide was synthesized containing a sequence motif present in the extracellular liga...

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Bibliographic Details
Published in:European journal of neurology 2005-05, Vol.12 (5), p.392-398
Main Authors: Omdal, R., Brokstad, K., Waterloo, K., Koldingsnes, W., Jonsson, R., Mellgren, S. I.
Format: Article
Language:English
Subjects:
Adult
Aged
anti-DNA antibodies
Autoantibodies - blood
Autoantibodies - immunology
Depression - etiology
Enzyme-Linked Immunosorbent Assay
Female
Humans
Lupus Erythematosus, Systemic - immunology
Lupus Erythematosus, Systemic - physiopathology
Lupus Erythematosus, Systemic - psychology
Male
Memory Disorders - etiology
Mental Disorders - etiology
Middle Aged
neuropsychiatric SLE
Neuropsychological Tests
NMDA receptor
Receptors, N-Methyl-D-Aspartate - immunology
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Summary:To determine whether neuropsychiatric manifestations in patients with systemic lupus erythematosus (SLE) are influenced by antibodies against the human N‐methyl‐d‐aspartate (NMDA) receptor types NR2a or NR2b. A decapeptide was synthesized containing a sequence motif present in the extracellular ligand‐binding domain of NMDA receptors NR2a and NR2b, bound by the monoclonal murine anti‐DNA antibody R4A. In an ELISA with the murine monoclonal R4v as positive control, plasma samples of 57 patients with SLE were examined for the anti‐peptide (anti‐NR2) antibody after the patients had been subjected to comprehensive psychological and cognitive testing. Poor performance on the Visual Paired Associates test (immediate), the Grooved Pegboard test, as well as high scores on the Beck Depression Inventory, and scales D‐2 (depression), Pd‐4 (psychopathic deviate), Sc‐8 (schizophrenia), and Ma‐9 (hypomania) of the MMPI‐2 were significantly associated with elevated levels of anti‐NR2 antibodies. The findings in several domains indicate an association between anti‐NR2 antibodies and depressed mood in addition to decreased short‐time memory and learning. Antibodies to NMDA receptors thus may represent one of several mechanisms for cerebral dysfunction in patients with SLE.
ISSN:1351-5101
1468-1331
DOI:10.1111/j.1468-1331.2004.00976.x