Hypoxia, angiogenesis and apoptosis markers in locally advanced rectal cancer

Hypoxia-inducible factor 1alpha (HIF-1alpha) is a critical regulatory protein of cellular response to hypoxia. HIF-1alpha triggers the angiogenic process through activation of the vascular endothelial factor (VEGF) gene. The bcl-2 anti-apoptotic and the death promoting p53 genes, regulate the apopto...

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Bibliographic Details
Published in:International journal of colorectal disease 2006-04, Vol.21 (3), p.248-257
Main Authors: THEODOROPOULOS, George E, LAZARIS, Andreas C, THEODOROPOULOS, Vasilios E, PAPATHEODOSIOU, Kalliopi, GAZOULI, Maria, BRAMIS, John, PATSOURIS, Efstratios, PANOUSSOPOULOS, Dimitrios
Format: Article
Language:English
Subjects:
Aged
Apoptosis
Biological and medical sciences
Biomarkers, Tumor - analysis
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Hypoxia
Immunohistochemistry
Male
Medical sciences
Neoplasm Invasiveness
Neoplasm Metastasis
Neoplasm Staging
Neovascularization, Pathologic
Rectal Neoplasms - blood supply
Rectal Neoplasms - pathology
Rectal Neoplasms - physiopathology
Rectal Neoplasms - surgery
Recurrence
Retrospective Studies
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
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Summary:Hypoxia-inducible factor 1alpha (HIF-1alpha) is a critical regulatory protein of cellular response to hypoxia. HIF-1alpha triggers the angiogenic process through activation of the vascular endothelial factor (VEGF) gene. The bcl-2 anti-apoptotic and the death promoting p53 genes, regulate the apoptotic cell death. We investigated the relationship between hypoxia, angiogenesis and apoptosis and their prognostic impact in patients with advanced rectal cancer. The immunohistochemical expression of HIF-1alpha, VEGF, p53 and bcl-2 and the determination of microvessel density (MVD), apoptotic index (AI) were carried out in tumour tissue samples obtained from 92 patients with locally advanced rectal cancer (LARC) (T3,4/N+/-). HIF-1alpha high reactivity and VEGF overexpression were noted in 47.8 and 44.6% of the examined cases, respectively. They significantly correlated with lymph node metastasis (P
ISSN:0179-1958
1432-1262
DOI:10.1007/s00384-005-0788-4