Acquisition-weighted MRSI for Detection and Quantification of BNCT 10B-carrier L-p-boronophenylalanine-fructose Complex, a Phantom Study

Proton magnetic resonance spectroscopy (1H MRS) is a potential method to detect and quantify a boron neutron capture therapy 10B-carrier compound, L-p-boronophenylalanine (BPA), in the brain. However, optimal positioning of MRS voxel to capture tissue with maximal BPA concentration can be challengin...

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Bibliographic Details
Published in:JOURNAL OF RADIATION RESEARCH 2009, Vol.50 (5), p.435-440
Main Authors: Timonen, Marjut, Kankaanranta, Leena, Lundbom, Nina, Kortesniemi, Mika, Seppälä, Tiina, Kouri, Mauri, Savolainen, Sauli, Heikkinen, Sami
Format: Article
Language:jpn ; eng
Subjects:
Algorithms
Animals
Boron Compounds - analysis
Boron Neutron Capture Therapy - methods
Brain Chemistry
Drug Carriers - analysis
Fructose - analogs & derivatives
Fructose - analysis
Humans
Magnetic Resonance Imaging - instrumentation
Magnetic Resonance Imaging - methods
Magnetic Resonance Spectroscopy - methods
Phantoms, Imaging
Protons
Reproducibility of Results
Sensitivity and Specificity
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Summary:Proton magnetic resonance spectroscopy (1H MRS) is a potential method to detect and quantify a boron neutron capture therapy 10B-carrier compound, L-p-boronophenylalanine (BPA), in the brain. However, optimal positioning of MRS voxel to capture tissue with maximal BPA concentration can be challenging. Three dimensional proton magnetic resonance spectroscopic imaging (3D 1H MRSI) provides spectral data covering a large spatial volume, which is a major advantage in detecting and quantifying BPA. BPA detection limit in phantom conditions was determined at 1.5 T using a 3D 1H MRSI protocol with clinically acceptable nominal spatial resolution and duration. Quantification tests for aqueous phantom were performed using both single voxel MRS and 3D MRSI. In 3D MRSI, BPA detection limit was ～1.0 mM and BPA quantification accuracy was better than ±5%. The results suggest that MRSI would be a feasible method for in vivo BPA evaluation in clinical conditions.
ISSN:0449-3060
1349-9157
DOI:10.1269/jrr.08127