TLR expression and NK cell activation after human yellow fever vaccination

Abstract The yellow fever vaccine is very effective with a single injection conferring protection for at least 10 years. Recent evidence suggests that the innate immune cells activated through Toll-like receptors (TLRs), are critical determinants of the robustness of the adaptive response. Therefore...

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Bibliographic Details
Published in:Vaccine 2009-09, Vol.27 (41), p.5543-5549
Main Authors: da Costa Neves, Patrícia Cristina, de Souza Matos, Denise Cristina, Marcovistz, Rugimar, Galler, Ricardo
Format: Article
Language:English
Subjects:
Adult
Allergy and Immunology
Antigens
Antigens, CD - biosynthesis
Applied microbiology
Arboviroses
Biological and medical sciences
CD16 antigen
Cloning
Cytotoxicity
Female
Flow cytometry
Fundamental and applied biological sciences. Psychology
HLA Antigens - biosynthesis
Human viral diseases
Humans
Immune system
Infections
Infectious diseases
Killer Cells, Natural - immunology
Lymphatic system
Lymphocyte Activation
Lymphocytes
Male
Medical sciences
Microbiology
Natural killer cells
Toll-like receptors
Toll-Like Receptors - biosynthesis
Tropical viral diseases
Up-Regulation
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Viral diseases
Yellow fever
Yellow Fever - prevention & control
Yellow fever vaccine
Yellow Fever Vaccine - immunology
Young Adult
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Summary:Abstract The yellow fever vaccine is very effective with a single injection conferring protection for at least 10 years. Recent evidence suggests that the innate immune cells activated through Toll-like receptors (TLRs), are critical determinants of the robustness of the adaptive response. Therefore, we investigated the NK cell status in eight healthy volunteers after vaccination with YF 17DD virus. Shortly after vaccination, we observed increased expression of TLR-3 and TLR-9 in NK cells and markers such as CD69, HLA-DP-DQ-DR, CD38 and CD16. The up-regulation of CD69 was positively correlated with the presence of TLRs throughout the post-vaccination period and the circulating IFN-γ was significantly augmented. These results suggest that TLRs may play an important role in NK cell activation during the immune response to vaccination, indicating a potential role for NK cells in helping the development of long-lasting protective memory.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2009.07.028