Isocaloric High-protein Diet Ameliorates Systolic Blood Pressure Increase and Cardiac Remodeling Caused by Maternal Caloric Restriction in Adult Mouse Offspring

Epidemiologic studies have shown that in utero malnutrition is a risk factor for adult cardiovascular disease (CVD). Recently, we reported a mouse animal model of 30% maternal caloric reduction, in which offspring showed a significant increase in systolic blood pressure (SBP) as well as in cardiac r...

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Bibliographic Details
Published in:ENDOCRINE JOURNAL 2009, Vol.56(5), pp.679-689
Main Authors: KAWAMURA, Makoto, ITOH, Hiroaki, YURA, Shigeo, MOGAMI, Haruta, FUJII, Tsuyoshi, MAKINO, Hisashi, MIYAMOTO, Yoshihiro, Yoshimasa, Yasunao, AOE, Seiichiro, OGAWA, Yoshihiro, SAGAWA, Norimasa, KANAYAMA, Norio, KONISHI, Ikuo
Format: Article
Language:eng ; jpn
Subjects:
Animals
Blood Pressure - physiology
Caloric Restriction
Cardiac remodeling
Cardiovascular Diseases - etiology
Cardiovascular Diseases - pathology
Corticosterone - blood
Dietary Proteins - administration & dosage
Female
Glucocorticoid
Hypertension - diet therapy
Malnutrition - complications
Maternal Nutritional Physiological Phenomena
Mice
Nutrition
Pregnancy
Prenatal Exposure Delayed Effects - diet therapy
Prenatal Nutritional Physiological Phenomena
Protein
Ventricular Remodeling - physiology
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Summary:Epidemiologic studies have shown that in utero malnutrition is a risk factor for adult cardiovascular disease (CVD). Recently, we reported a mouse animal model of 30% maternal caloric reduction, in which offspring showed a significant increase in systolic blood pressure (SBP) as well as in cardiac remodeling-associated morphological parameters such as cardiac enlargement and coronary perivascular fibrosis in adulthood. Using a similar animal model, we here demonstrated that an increased level of protein consumption during an undernourished pregnancy (high-protein diet; HPD) corrected for the development of CVD risk factors found in fetal undernourishment with less protein consumption (standardprotein diet; SPD). In contrast, maternal ad libitum feeding with HPD resulted in significantly elevated SBP and cardiac enlargement in offspring at 16 wks. Appropriate maternal protein ingestion might partly protect against the development of CVD risk factors in offspring.
ISSN:0918-8959
1348-4540
DOI:10.1507/endocrj.K08E-286