Long-term Outcome for Large Meniscal Defects Treated With Small Intestinal Submucosa in a Dog Model

Background: Large meniscal defects are a common problem for which current treatment options are limited. Hypothesis: Treatment of posterior medial meniscal defects in dogs with small intestinal submucosa is superior to partial meniscectomy in terms of clinical limb function, chondroprotection, and a...

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Bibliographic Details
Published in:The American journal of sports medicine 2006-01, Vol.34 (1), p.32-42
Main Authors: Cook, James L., Fox, Derek B., Malaviya, Prasanna, Tomlinson, James L., Kuroki, Keiichi, Cook, Cristi Reeves, Kladakis, Stephanie
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cartilage implants
Complications and side effects
Deformities
Diseases of the osteoarticular system
Dogs
Excision (Surgery)
Injuries
Intestinal Mucosa - transplantation
Intestine, Small
Knee
Knee joint
Knee Joint - surgery
Medical sciences
Menisci, Tibial - abnormalities
Menisci, Tibial - surgery
Meniscus (Anatomy)
Physiological aspects
Sports medicine
Surgical Procedures, Operative - veterinary
Tissue engineering
Transplants & implants
Treatment Outcome
United States
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Summary:Background: Large meniscal defects are a common problem for which current treatment options are limited. Hypothesis: Treatment of posterior medial meniscal defects in dogs with small intestinal submucosa is superior to partial meniscectomy in terms of clinical limb function, chondroprotection, and amount and type of new tissue in the defect. Study Design: Controlled laboratory study. Methods: A total of 51 mongrel dogs underwent medial arthrotomy with creation of standardized meniscal defects. The dogs were divided into groups based on defect treatment: small intestinal submucosa meniscal implant (n = 29) or meniscectomy (n = 22). The dogs were assessed for lameness by subjective scoring after surgery and sacrificed at 3, 6, or 12 months and assessed for articular cartilage damage, gross and histologic appearance of the operated meniscus, amount of new tissue in the defect, equilibrium compressive modulus of meniscal tissue, and relative compressive stiffness of articular cartilage. Results: Dogs in the meniscectomy groups were significantly ( P < .001) more lame than dogs treated with small intestinal submucosa. Joints treated with small intestinal submucosa had significantly ( P
ISSN:0363-5465
1552-3365
DOI:10.1177/0363546505278702