Lipoprotein-associated phospholipase A2 is associated with risk of dementia

Objective High levels of the inflammatory marker lipoprotein‐associated phospholipase A2 (Lp‐PLA2) have been proposed to be a predictor of coronary heart disease and stroke. Because both inflammation and vascular disease are associated with dementia, the objective of the present study was to examine...

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Bibliographic Details
Published in:Annals of neurology 2006-01, Vol.59 (1), p.139-144
Main Authors: van Oijen, Marieke, van der Meer, Irene M., Hofman, Albert, Witteman, Jacqueline C. M., Koudstaal, Peter J., Breteler, Monique M. B.
Format: Article
Language:English
Subjects:
1-Alkyl-2-acetylglycerophosphocholine Esterase
Aged
Biological and medical sciences
Cohort Studies
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dementia - metabolism
Female
Human viral diseases
Humans
Infectious diseases
Male
Medical sciences
Middle Aged
Neurology
Phospholipases A - blood
Phospholipases A2
Proportional Hazards Models
Random Allocation
Risk Factors
Viral diseases
Viral diseases of the nervous system
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Summary:Objective High levels of the inflammatory marker lipoprotein‐associated phospholipase A2 (Lp‐PLA2) have been proposed to be a predictor of coronary heart disease and stroke. Because both inflammation and vascular disease are associated with dementia, the objective of the present study was to examine the association between Lp‐PLA2 and the risk of dementia. Methods Within the Rotterdam Study, a population‐based prospective cohort study, we performed a case–cohort study. Of the 6,713 participants at risk for dementia, a random sample of 1,742 individuals was drawn. During follow‐up (mean, 5.7 years), 302 incident dementia cases were identified. Cox proportional hazard models were used to estimate the association of Lp‐PLA2 and dementia. Results We found that subjects with higher levels of Lp‐PLA2 had an increased risk of dementia. Compared with the first quartile of Lp‐PLA2, age‐ and sex‐adjusted hazard ratios (HRs; 95% confidence interval [CI]) for dementia for the second, third, and fourth quartiles were 1.19 (0.78–1.81), 1.15 (0.74–1.79), and 1.56 (1.03–2.37), respectively (p value for trend 0.04). Additional adjustment for cardiovascular and inflammatory factors did not change the estimates. Interpretation This is the first study to our knowledge that shows that Lp‐PLA2 is associated with the risk of dementia independent of cardiovascular and inflammatory factors and provides evidence for a potential role of Lp‐PLA2 in identifying subjects at risk for dementia. Ann Neurol 2006
ISSN:0364-5134
1531-8249
DOI:10.1002/ana.20721