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Peptide-induced immune protection of CD8+ T cell-deficient mice against Friend retrovirus-induced disease
CD8+ CTLs and virus-neutralizing antibodies have been associated with spontaneous and vaccine-induced immune control of retroviral infections. We previously showed that a single immunization with an env gene-encoded CD4+ T cell epitope protected mice against fatal Friend retrovirus infection. Here,...
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| Published in: | International immunology 2006-01, Vol.18 (1), p.183-198 |
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| creator | Kawabata, Hiroyuki Niwa, Atsuko Tsuji-Kawahara, Sachiyo Uenishi, Hirohide Iwanami, Norimasa Matsukuma, Hideaki Abe, Hiroyuki Tabata, Nobutada Matsumura, Haruo Miyazawa, Masaaki |
| description | CD8+ CTLs and virus-neutralizing antibodies have been associated with spontaneous and vaccine-induced immune control of retroviral infections. We previously showed that a single immunization with an env gene-encoded CD4+ T cell epitope protected mice against fatal Friend retrovirus infection. Here, we analyzed immune cell components required for the peptide-induced anti-retroviral protection. Mice lacking CD8+ T cells were nevertheless protected against Friend virus infection, while mice lacking B cells were not. Virus-producing cells both in the spleen and bone marrow decreased rapidly in their number and became undetectable by 4 weeks after infection in the majority of the peptide-immunized animals even in the absence of CD8+ T cells. In the vaccinated animals the production and class switching of virus-neutralizing and anti-leukemia cell antibodies were facilitated; however, virus-induced erythroid cell expansion was suppressed before neutralizing antibodies became detectable in the serum. Further, the numbers of virus-producing cells in the spleen and bone marrow in the early stage of the infection were smaller in the peptide-immunized than in unimmunized control mice in the absence of B cells. Thus, peptide immunization facilitates both early cellular and late humoral immune responses that lead to the effective control of the retrovirus-induced disease, but CD8+ T cells are not crucial for the elimination of virus-infected cells in the peptide-primed animals. |
| doi_str_mv | 10.1093/intimm/dxh361 |
| format | article |
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We previously showed that a single immunization with an env gene-encoded CD4+ T cell epitope protected mice against fatal Friend retrovirus infection. Here, we analyzed immune cell components required for the peptide-induced anti-retroviral protection. Mice lacking CD8+ T cells were nevertheless protected against Friend virus infection, while mice lacking B cells were not. Virus-producing cells both in the spleen and bone marrow decreased rapidly in their number and became undetectable by 4 weeks after infection in the majority of the peptide-immunized animals even in the absence of CD8+ T cells. In the vaccinated animals the production and class switching of virus-neutralizing and anti-leukemia cell antibodies were facilitated; however, virus-induced erythroid cell expansion was suppressed before neutralizing antibodies became detectable in the serum. Further, the numbers of virus-producing cells in the spleen and bone marrow in the early stage of the infection were smaller in the peptide-immunized than in unimmunized control mice in the absence of B cells. Thus, peptide immunization facilitates both early cellular and late humoral immune responses that lead to the effective control of the retrovirus-induced disease, but CD8+ T cells are not crucial for the elimination of virus-infected cells in the peptide-primed animals.</description><identifier>ISSN: 0953-8178</identifier><identifier>EISSN: 1460-2377</identifier><identifier>DOI: 10.1093/intimm/dxh361</identifier><identifier>PMID: 16352628</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject><![CDATA[7-AAD 7-aminoactinomycin D ; Animals ; Antibodies, Viral - immunology ; APC antigen-presenting cell ; B cell-deficient ; B-Lymphocytes ; B6 C57BL/6 ; Bone Marrow - immunology ; Bone Marrow - virology ; CB6F1 (BALB/c × C56BL/6)F1 ; CD4+ T ; CD4-Positive T-Lymphocytes - immunology ; CD8-Positive T-Lymphocytes ; ED50 dose required to induce 50% of the maximum response ; epitope ; Epitopes, T-Lymphocyte - administration & dosage ; Epitopes, T-Lymphocyte - immunology ; F-MuLV Friend murine leukemia virus ; FBS fetal bovine serum ; Friend murine leukemia virus - immunology ; FV Friend retrovirus complex ; Gene Products, env - administration & dosage ; Gene Products, env - immunology ; Leukemia, Experimental - immunology ; Leukemia, Experimental - prevention & control ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; PBBS phosphate-buffered balanced salt solution ; PID post-infection day ; Retroviridae Infections - immunology ; Retroviridae Infections - prevention & control ; SFFU spleen focus-forming unit ; SFFV spleen focus-forming virus ; Spleen - immunology ; Spleen - virology ; Tumor Virus Infections - immunology ; Tumor Virus Infections - prevention & control ; Vaccination - methods ; vaccine ; Viral Vaccines - administration & dosage ; Viral Vaccines - immunology ; β2-microglobulin-deficient ; β2m β2-microglobulin ; μMT Ig μ-chain membrane exon-targeted]]></subject><ispartof>International immunology, 2006-01, Vol.18 (1), p.183-198</ispartof><rights>Copyright Oxford University Press(England) Jan 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-b74dcf082c5a9b59476b09a31f59f26f6f033a74ba0bfac2c40f36ed8c982863</citedby><cites>FETCH-LOGICAL-c448t-b74dcf082c5a9b59476b09a31f59f26f6f033a74ba0bfac2c40f36ed8c982863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16352628$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kawabata, Hiroyuki</creatorcontrib><creatorcontrib>Niwa, Atsuko</creatorcontrib><creatorcontrib>Tsuji-Kawahara, Sachiyo</creatorcontrib><creatorcontrib>Uenishi, Hirohide</creatorcontrib><creatorcontrib>Iwanami, Norimasa</creatorcontrib><creatorcontrib>Matsukuma, Hideaki</creatorcontrib><creatorcontrib>Abe, Hiroyuki</creatorcontrib><creatorcontrib>Tabata, Nobutada</creatorcontrib><creatorcontrib>Matsumura, Haruo</creatorcontrib><creatorcontrib>Miyazawa, Masaaki</creatorcontrib><title>Peptide-induced immune protection of CD8+ T cell-deficient mice against Friend retrovirus-induced disease</title><title>International immunology</title><addtitle>Int. Immunol</addtitle><description>CD8+ CTLs and virus-neutralizing antibodies have been associated with spontaneous and vaccine-induced immune control of retroviral infections. We previously showed that a single immunization with an env gene-encoded CD4+ T cell epitope protected mice against fatal Friend retrovirus infection. Here, we analyzed immune cell components required for the peptide-induced anti-retroviral protection. Mice lacking CD8+ T cells were nevertheless protected against Friend virus infection, while mice lacking B cells were not. Virus-producing cells both in the spleen and bone marrow decreased rapidly in their number and became undetectable by 4 weeks after infection in the majority of the peptide-immunized animals even in the absence of CD8+ T cells. In the vaccinated animals the production and class switching of virus-neutralizing and anti-leukemia cell antibodies were facilitated; however, virus-induced erythroid cell expansion was suppressed before neutralizing antibodies became detectable in the serum. Further, the numbers of virus-producing cells in the spleen and bone marrow in the early stage of the infection were smaller in the peptide-immunized than in unimmunized control mice in the absence of B cells. Thus, peptide immunization facilitates both early cellular and late humoral immune responses that lead to the effective control of the retrovirus-induced disease, but CD8+ T cells are not crucial for the elimination of virus-infected cells in the peptide-primed animals.</description><subject>7-AAD 7-aminoactinomycin D</subject><subject>Animals</subject><subject>Antibodies, Viral - immunology</subject><subject>APC antigen-presenting cell</subject><subject>B cell-deficient</subject><subject>B-Lymphocytes</subject><subject>B6 C57BL/6</subject><subject>Bone Marrow - immunology</subject><subject>Bone Marrow - virology</subject><subject>CB6F1 (BALB/c × C56BL/6)F1</subject><subject>CD4+ T</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>CD8-Positive T-Lymphocytes</subject><subject>ED50 dose required to induce 50% of the maximum response</subject><subject>epitope</subject><subject>Epitopes, T-Lymphocyte - administration & dosage</subject><subject>Epitopes, T-Lymphocyte - immunology</subject><subject>F-MuLV Friend murine leukemia virus</subject><subject>FBS fetal bovine serum</subject><subject>Friend murine leukemia virus - immunology</subject><subject>FV Friend retrovirus complex</subject><subject>Gene Products, env - administration & dosage</subject><subject>Gene Products, env - immunology</subject><subject>Leukemia, Experimental - immunology</subject><subject>Leukemia, Experimental - prevention & control</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Knockout</subject><subject>PBBS phosphate-buffered balanced salt solution</subject><subject>PID post-infection day</subject><subject>Retroviridae Infections - immunology</subject><subject>Retroviridae Infections - prevention & control</subject><subject>SFFU spleen focus-forming unit</subject><subject>SFFV spleen focus-forming virus</subject><subject>Spleen - immunology</subject><subject>Spleen - virology</subject><subject>Tumor Virus Infections - immunology</subject><subject>Tumor Virus Infections - prevention & control</subject><subject>Vaccination - methods</subject><subject>vaccine</subject><subject>Viral Vaccines - administration & dosage</subject><subject>Viral Vaccines - immunology</subject><subject>β2-microglobulin-deficient</subject><subject>β2m β2-microglobulin</subject><subject>μMT Ig μ-chain membrane exon-targeted</subject><issn>0953-8178</issn><issn>1460-2377</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNpdkM1LHDEYh4NU6mp77LWEHrzI1GQyk4-jXT-2ILbFPYiXkEnetNGdmW2SEf3vjeyi4CmQPDz88iD0hZLvlCh2HIYc-v7YPf5jnO6gGW04qWomxAc0I6pllaRC7qH9lO4IIaxW7CPao5y1Na_lDIXfsM7BQRUGN1lwuMimAfA6jhlsDuOAR4_np_IIL7GF1apy4IMNMGTcBwvY_DVhSBmfx3LncIQcx4cQp_RqdCGBSfAJ7XqzSvB5ex6g5fnZcr6oLn9d_JyfXFa2aWSuOtE464msbWtU16pG8I4ow6hvla-5554wZkTTGdJ5Y2vbEM84OGmVrCVnB-hwoy0_-D9ByroP6WW4GWCckuaiOJUQBfz2DrwbpziUaZqqlpR2rSpQtYFsHFOK4PU6ht7EJ02JfumvN_31pn_hv26lU9eDe6O3wd-EIWV4fH038b4sY6LVi5tbfXWt_gjKhf7BngEJS5La</recordid><startdate>200601</startdate><enddate>200601</enddate><creator>Kawabata, Hiroyuki</creator><creator>Niwa, Atsuko</creator><creator>Tsuji-Kawahara, Sachiyo</creator><creator>Uenishi, Hirohide</creator><creator>Iwanami, Norimasa</creator><creator>Matsukuma, Hideaki</creator><creator>Abe, Hiroyuki</creator><creator>Tabata, Nobutada</creator><creator>Matsumura, Haruo</creator><creator>Miyazawa, Masaaki</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200601</creationdate><title>Peptide-induced immune protection of CD8+ T cell-deficient mice against Friend retrovirus-induced disease</title><author>Kawabata, Hiroyuki ; 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Immunol</addtitle><date>2006-01</date><risdate>2006</risdate><volume>18</volume><issue>1</issue><spage>183</spage><epage>198</epage><pages>183-198</pages><issn>0953-8178</issn><eissn>1460-2377</eissn><notes>istex:2E76D05469A5BBEAB4C0B42A987DD85F2E9C7DC5</notes><notes>local:dxh361</notes><notes>Correspondence to: M. Miyazawa; E-mail: masaaki@med.kindai.ac.jp</notes><notes>ark:/67375/HXZ-NS9Q7167-B</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>CD8+ CTLs and virus-neutralizing antibodies have been associated with spontaneous and vaccine-induced immune control of retroviral infections. We previously showed that a single immunization with an env gene-encoded CD4+ T cell epitope protected mice against fatal Friend retrovirus infection. Here, we analyzed immune cell components required for the peptide-induced anti-retroviral protection. Mice lacking CD8+ T cells were nevertheless protected against Friend virus infection, while mice lacking B cells were not. Virus-producing cells both in the spleen and bone marrow decreased rapidly in their number and became undetectable by 4 weeks after infection in the majority of the peptide-immunized animals even in the absence of CD8+ T cells. In the vaccinated animals the production and class switching of virus-neutralizing and anti-leukemia cell antibodies were facilitated; however, virus-induced erythroid cell expansion was suppressed before neutralizing antibodies became detectable in the serum. Further, the numbers of virus-producing cells in the spleen and bone marrow in the early stage of the infection were smaller in the peptide-immunized than in unimmunized control mice in the absence of B cells. Thus, peptide immunization facilitates both early cellular and late humoral immune responses that lead to the effective control of the retrovirus-induced disease, but CD8+ T cells are not crucial for the elimination of virus-infected cells in the peptide-primed animals.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>16352628</pmid><doi>10.1093/intimm/dxh361</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | International immunology, 2006-01, Vol.18 (1), p.183-198 |
| issn | 0953-8178 1460-2377 |
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| source | Oxford Journals Online |
| subjects | 7-AAD 7-aminoactinomycin D Animals Antibodies, Viral - immunology APC antigen-presenting cell B cell-deficient B-Lymphocytes B6 C57BL/6 Bone Marrow - immunology Bone Marrow - virology CB6F1 (BALB/c × C56BL/6)F1 CD4+ T CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes ED50 dose required to induce 50% of the maximum response epitope Epitopes, T-Lymphocyte - administration & dosage Epitopes, T-Lymphocyte - immunology F-MuLV Friend murine leukemia virus FBS fetal bovine serum Friend murine leukemia virus - immunology FV Friend retrovirus complex Gene Products, env - administration & dosage Gene Products, env - immunology Leukemia, Experimental - immunology Leukemia, Experimental - prevention & control Mice Mice, Inbred BALB C Mice, Knockout PBBS phosphate-buffered balanced salt solution PID post-infection day Retroviridae Infections - immunology Retroviridae Infections - prevention & control SFFU spleen focus-forming unit SFFV spleen focus-forming virus Spleen - immunology Spleen - virology Tumor Virus Infections - immunology Tumor Virus Infections - prevention & control Vaccination - methods vaccine Viral Vaccines - administration & dosage Viral Vaccines - immunology β2-microglobulin-deficient β2m β2-microglobulin μMT Ig μ-chain membrane exon-targeted |
| title | Peptide-induced immune protection of CD8+ T cell-deficient mice against Friend retrovirus-induced disease |
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