Elevated serum urate concentration independently predicts poor outcome following stroke in patients with diabetes

Background Type 2 diabetes is a risk factor for stroke and confers increased risk of poor outcome and further vascular events following stroke. Hyperuricaemia occurs commonly in patients with type 2 diabetes, but its significance as a predictor of outcome following stroke is uncertain. We sought to...

Full description

Saved in:
Bibliographic Details
Published in:Diabetes/metabolism research and reviews 2006-01, Vol.22 (1), p.79-82
Main Authors: Newman, Edward J., Rahman, Fariel S., Lees, Kennedy R., Weir, Christopher J., Walters, Matthew R.
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Brain Ischemia - blood
Brain Ischemia - diagnosis
Brain Ischemia - mortality
Cerebral Hemorrhage - blood
Cerebral Hemorrhage - diagnosis
Cerebral Hemorrhage - mortality
Cohort Studies
Diabetes Mellitus, Type 2 - complications
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
Follow-Up Studies
Humans
Ischemic Attack, Transient - blood
Ischemic Attack, Transient - diagnosis
Ischemic Attack, Transient - mortality
Male
Medical sciences
Neurology
outcome
Outcome Assessment (Health Care) - methods
Prognosis
Risk Factors
stroke
Stroke - blood
Stroke - diagnosis
Stroke - mortality
Survival Rate
Uric Acid - blood
Vascular diseases and vascular malformations of the nervous system
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Type 2 diabetes is a risk factor for stroke and confers increased risk of poor outcome and further vascular events following stroke. Hyperuricaemia occurs commonly in patients with type 2 diabetes, but its significance as a predictor of outcome following stroke is uncertain. We sought to investigate the prognostic significance of elevated serum urate concentration in diabetic subjects following stroke. Methods We studied a cohort of type 2 diabetes patients presenting to our unit with computed tomography‐confirmed acute stroke. Fasting blood samples were drawn within 24 h of admission for urate concentration and standard battery of biochemistry and hematological tests. Information on age, stroke type, prior hypertension, smoking status, resolution time of symptoms and National Institutes of Health Stroke Score was collated. The main outcome event was time to myocardial infarction, recurrent stroke or vascular death, as defined in the CAPRIE trial. Stepwise proportional hazards regression was used to estimate the effect of the above variables on event‐free survival following stroke. Results One hundred and forty patients were studied. Median follow‐up duration was 974 days (IQR 163 to 1830 days). Sixty‐four patients suffered an outcome event. Urate levels of greater than 0.42 mmol/L (p < 0.001) and an increasing NIHSS score (p < 0.001) independently predicted increased likelihood of suffering an event. Conclusion Elevated urate concentration is significantly and independently associated with increased risk of future vascular events in diabetic stroke patients. Further studies to elucidate the mechanism of this observation are required. Copyright © 2005 John Wiley & Sons, Ltd.
ISSN:1520-7552
1520-7560
DOI:10.1002/dmrr.585