Prevaccination genomic diversity of human papillomavirus genotype 6 (HPV 6)

Abstract Prevaccination genomic diversity of human papillomavirus genotype 6 (HPV 6) was established by sequencing 3798 bp of 77 clinically important HPV 6 isolates obtained from 45 and 32 patients with genital warts and laryngeal papillomas, respectively. By analyzing pooled L1, LCR, E6, E2, and E5...

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Bibliographic Details
Published in:Virology (New York, N.Y.) N.Y.), 2009-09, Vol.391 (2), p.274-283
Main Authors: Kocjan, Boštjan J, Poljak, Mario, Cimerman, Mojca, Gale, Nina, Potočnik, Marko, Bogovac, Željka, Seme, Katja
Format: Article
Language:English
Subjects:
Base Sequence
Cluster Analysis
Condylomata Acuminata - virology
DNA, Viral - chemistry
DNA, Viral - genetics
Female
Genital warts
Genomic diversity
Genomic variants
Genotype
HPV
HPV 6
Human papillomavirus
Human papillomavirus 6 - classification
Human papillomavirus 6 - genetics
Human papillomavirus 6 - isolation & purification
Human papillomaviruses
Humans
Infectious Disease
Laryngeal Neoplasms - virology
Laryngeal papillomas
Male
Molecular Sequence Data
Mutation
Papilloma - virology
Papillomavirus Infections - virology
Polymorphism, Genetic
Sequence Analysis, DNA
Sequence Homology
Slovenia
Vaccine
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Summary:Abstract Prevaccination genomic diversity of human papillomavirus genotype 6 (HPV 6) was established by sequencing 3798 bp of 77 clinically important HPV 6 isolates obtained from 45 and 32 patients with genital warts and laryngeal papillomas, respectively. By analyzing pooled L1, LCR, E6, E2, and E5 nucleotide data of an individual isolate, a total of 36 different genomic variants were identified, of which six (12 isolates), one (one isolate) and 29 (64 isolates) corresponded to HPV 6b, HPV 6a, and HPV 6vc genetic lineages, respectively. Several novel, potentially important mutations were identified. Non-prototypic HPV 6vc genomic variants were found in the majority of genital warts and laryngeal papillomas included in the study. The presence of serious HPV 6 genome sequence errors was confirmed and novel sequence errors were identified in sequence repositories.
ISSN:0042-6822
1096-0341
DOI:10.1016/j.virol.2009.06.030