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Vaginal versus sublingual misoprostol for second-trimester pregnancy termination and effect on Doppler measurements
Abstract Objective To compare the efficacy of vaginal versus sublingual misoprostol for second-trimester pregnancy termination, and to evaluate the effect on the blood flow of the uterine and umbilical arteries. Methods Forty-nine patients were randomized to receive either 200 μg of vaginal misopros...
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| Published in: | International journal of gynecology and obstetrics 2009-09, Vol.106 (3), p.250-253 |
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| container_issue | 3 |
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| container_title | International journal of gynecology and obstetrics |
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| creator | Karsidag, A. Yasemin Karageyim Buyukbayrak, Esra E. Kars, Bulent Dansuk, Ramazan Unal, Orhan Turan, M. Cem |
| description | Abstract Objective To compare the efficacy of vaginal versus sublingual misoprostol for second-trimester pregnancy termination, and to evaluate the effect on the blood flow of the uterine and umbilical arteries. Methods Forty-nine patients were randomized to receive either 200 μg of vaginal misoprostol every 6 hours or 200 μg of misoprostol sublingually every 6 hours. Doppler velocimetry studies were assessed immediately before and 60 minutes after the administration of the first dose. Standard descriptive calculations, Mann–Whitney U, Wilcoxon, and χ2 tests were performed. Results The mean interval between induction and onset of active labor, induction and delivery, and the duration of oxytocin administration were significantly shorter in the sublingual misoprostol group. Both routes of administration increased the Doppler indices for the uterine arteries; however, misoprostol via the sublingual route did not affect the umbilical arteries. Conclusion Sublingual administration of misoprostol for second-trimester medical abortion results in a higher success rate and does not affect umbilical blood flow. |
| doi_str_mv | 10.1016/j.ijgo.2009.04.001 |
| format | article |
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Yasemin Karageyim ; Buyukbayrak, Esra E. ; Kars, Bulent ; Dansuk, Ramazan ; Unal, Orhan ; Turan, M. Cem</creator><creatorcontrib>Karsidag, A. Yasemin Karageyim ; Buyukbayrak, Esra E. ; Kars, Bulent ; Dansuk, Ramazan ; Unal, Orhan ; Turan, M. Cem</creatorcontrib><description>Abstract Objective To compare the efficacy of vaginal versus sublingual misoprostol for second-trimester pregnancy termination, and to evaluate the effect on the blood flow of the uterine and umbilical arteries. Methods Forty-nine patients were randomized to receive either 200 μg of vaginal misoprostol every 6 hours or 200 μg of misoprostol sublingually every 6 hours. Doppler velocimetry studies were assessed immediately before and 60 minutes after the administration of the first dose. Standard descriptive calculations, Mann–Whitney U, Wilcoxon, and χ2 tests were performed. Results The mean interval between induction and onset of active labor, induction and delivery, and the duration of oxytocin administration were significantly shorter in the sublingual misoprostol group. Both routes of administration increased the Doppler indices for the uterine arteries; however, misoprostol via the sublingual route did not affect the umbilical arteries. Conclusion Sublingual administration of misoprostol for second-trimester medical abortion results in a higher success rate and does not affect umbilical blood flow.</description><identifier>ISSN: 0020-7292</identifier><identifier>EISSN: 1879-3479</identifier><identifier>DOI: 10.1016/j.ijgo.2009.04.001</identifier><identifier>PMID: 19428005</identifier><identifier>CODEN: IJGOAL</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Abortifacient Agents, Nonsteroidal - administration & dosage ; Abortion, Induced - methods ; Administration, Intravaginal ; Administration, Sublingual ; Biological and medical sciences ; Birth control ; Blood Flow Velocity - drug effects ; Cardiovascular system ; Digestive system ; Doppler measurement ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Induced abortion. Therapeutic abortion ; Investigative techniques, diagnostic techniques (general aspects) ; Laser-Doppler Flowmetry ; Medical sciences ; Misoprostol - administration & dosage ; Obstetrics and Gynecology ; Pharmacology. Drug treatments ; Pregnancy ; Pregnancy Trimester, Second ; Regional Blood Flow - drug effects ; Second-trimester termination ; Sublingual misoprostol ; Treatment Outcome ; Ultrasonic investigative techniques ; Ultrasonography ; Umbilical Arteries - diagnostic imaging ; Umbilical Arteries - drug effects ; Uterus - blood supply ; Vaginal misoprostol</subject><ispartof>International journal of gynecology and obstetrics, 2009-09, Vol.106 (3), p.250-253</ispartof><rights>International Federation of Gynecology and Obstetrics</rights><rights>2009 International Federation of Gynecology and Obstetrics</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4870-33962d5b0f074ccc94ccd203c5a995a1336a050f3059c0f405f51b125a760c673</citedby><cites>FETCH-LOGICAL-c4870-33962d5b0f074ccc94ccd203c5a995a1336a050f3059c0f405f51b125a760c673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.ijgo.2009.04.001$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1016%2Fj.ijgo.2009.04.001$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21879852$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19428005$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karsidag, A. Yasemin Karageyim</creatorcontrib><creatorcontrib>Buyukbayrak, Esra E.</creatorcontrib><creatorcontrib>Kars, Bulent</creatorcontrib><creatorcontrib>Dansuk, Ramazan</creatorcontrib><creatorcontrib>Unal, Orhan</creatorcontrib><creatorcontrib>Turan, M. Cem</creatorcontrib><title>Vaginal versus sublingual misoprostol for second-trimester pregnancy termination and effect on Doppler measurements</title><title>International journal of gynecology and obstetrics</title><addtitle>Int J Gynaecol Obstet</addtitle><description>Abstract Objective To compare the efficacy of vaginal versus sublingual misoprostol for second-trimester pregnancy termination, and to evaluate the effect on the blood flow of the uterine and umbilical arteries. Methods Forty-nine patients were randomized to receive either 200 μg of vaginal misoprostol every 6 hours or 200 μg of misoprostol sublingually every 6 hours. Doppler velocimetry studies were assessed immediately before and 60 minutes after the administration of the first dose. Standard descriptive calculations, Mann–Whitney U, Wilcoxon, and χ2 tests were performed. Results The mean interval between induction and onset of active labor, induction and delivery, and the duration of oxytocin administration were significantly shorter in the sublingual misoprostol group. Both routes of administration increased the Doppler indices for the uterine arteries; however, misoprostol via the sublingual route did not affect the umbilical arteries. Conclusion Sublingual administration of misoprostol for second-trimester medical abortion results in a higher success rate and does not affect umbilical blood flow.</description><subject>Abortifacient Agents, Nonsteroidal - administration & dosage</subject><subject>Abortion, Induced - methods</subject><subject>Administration, Intravaginal</subject><subject>Administration, Sublingual</subject><subject>Biological and medical sciences</subject><subject>Birth control</subject><subject>Blood Flow Velocity - drug effects</subject><subject>Cardiovascular system</subject><subject>Digestive system</subject><subject>Doppler measurement</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Induced abortion. Therapeutic abortion</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Laser-Doppler Flowmetry</subject><subject>Medical sciences</subject><subject>Misoprostol - administration & dosage</subject><subject>Obstetrics and Gynecology</subject><subject>Pharmacology. Drug treatments</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, Second</subject><subject>Regional Blood Flow - drug effects</subject><subject>Second-trimester termination</subject><subject>Sublingual misoprostol</subject><subject>Treatment Outcome</subject><subject>Ultrasonic investigative techniques</subject><subject>Ultrasonography</subject><subject>Umbilical Arteries - diagnostic imaging</subject><subject>Umbilical Arteries - drug effects</subject><subject>Uterus - blood supply</subject><subject>Vaginal misoprostol</subject><issn>0020-7292</issn><issn>1879-3479</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNqNkk1v1DAQhiMEotvCH-CAcoFblrETx7GEkFCBUlSpBz7EzfI6k5WXJF48SdH--060K5A4IC7-0vOO_b6eLHsmYC1A1K9267DbxrUEMGuo1gDiQbYSjTZFWWnzMFsBSCi0NPIsOyfaARNaiMfZmTCVbADUKqNvbhtG1-d3mGimnOZNH8btzCdDoLhPkabY511MOaGPY1tMKQxIE6Z8n3A7utEfct4NXGUKcczd2ObYdeinnHfv4n7fMzugoznhgONET7JHnesJn57mi-zrh_dfLj8WN7dX15dvbwpfNRqKsjS1bNUGOtCV997w0EoovXLGKCfKsnagoCtBGQ9dBapTYiOkcroGX-vyInt5rMsufs78ZsuWPPa9GzHOZGutdFM3ikF5BD3bpYSd3bNJlw5WgF2itju7RG2XqC1UloNk0fNT9XkzYPtHcsqWgRcnwJF3fZc4qkC_Obn8VKMkc_rI_Qo9Hv7janv96epWKmDl66MSOcW7gMmSDzh6bEPi_G0bw78dvPlL7vnvA7_1Bx6QdnFO3BlkhSVpwX5e2mnpJjDLSnwv7wH4tsSu</recordid><startdate>200909</startdate><enddate>200909</enddate><creator>Karsidag, A. Yasemin Karageyim</creator><creator>Buyukbayrak, Esra E.</creator><creator>Kars, Bulent</creator><creator>Dansuk, Ramazan</creator><creator>Unal, Orhan</creator><creator>Turan, M. Cem</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200909</creationdate><title>Vaginal versus sublingual misoprostol for second-trimester pregnancy termination and effect on Doppler measurements</title><author>Karsidag, A. Yasemin Karageyim ; Buyukbayrak, Esra E. ; Kars, Bulent ; Dansuk, Ramazan ; Unal, Orhan ; Turan, M. Cem</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4870-33962d5b0f074ccc94ccd203c5a995a1336a050f3059c0f405f51b125a760c673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Abortifacient Agents, Nonsteroidal - administration & dosage</topic><topic>Abortion, Induced - methods</topic><topic>Administration, Intravaginal</topic><topic>Administration, Sublingual</topic><topic>Biological and medical sciences</topic><topic>Birth control</topic><topic>Blood Flow Velocity - drug effects</topic><topic>Cardiovascular system</topic><topic>Digestive system</topic><topic>Doppler measurement</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Induced abortion. Therapeutic abortion</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Laser-Doppler Flowmetry</topic><topic>Medical sciences</topic><topic>Misoprostol - administration & dosage</topic><topic>Obstetrics and Gynecology</topic><topic>Pharmacology. Drug treatments</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, Second</topic><topic>Regional Blood Flow - drug effects</topic><topic>Second-trimester termination</topic><topic>Sublingual misoprostol</topic><topic>Treatment Outcome</topic><topic>Ultrasonic investigative techniques</topic><topic>Ultrasonography</topic><topic>Umbilical Arteries - diagnostic imaging</topic><topic>Umbilical Arteries - drug effects</topic><topic>Uterus - blood supply</topic><topic>Vaginal misoprostol</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karsidag, A. Yasemin Karageyim</creatorcontrib><creatorcontrib>Buyukbayrak, Esra E.</creatorcontrib><creatorcontrib>Kars, Bulent</creatorcontrib><creatorcontrib>Dansuk, Ramazan</creatorcontrib><creatorcontrib>Unal, Orhan</creatorcontrib><creatorcontrib>Turan, M. Cem</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karsidag, A. Yasemin Karageyim</au><au>Buyukbayrak, Esra E.</au><au>Kars, Bulent</au><au>Dansuk, Ramazan</au><au>Unal, Orhan</au><au>Turan, M. Cem</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vaginal versus sublingual misoprostol for second-trimester pregnancy termination and effect on Doppler measurements</atitle><jtitle>International journal of gynecology and obstetrics</jtitle><addtitle>Int J Gynaecol Obstet</addtitle><date>2009-09</date><risdate>2009</risdate><volume>106</volume><issue>3</issue><spage>250</spage><epage>253</epage><pages>250-253</pages><issn>0020-7292</issn><eissn>1879-3479</eissn><coden>IJGOAL</coden><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-News-1</notes><notes>ObjectType-Feature-3</notes><notes>content type line 23</notes><abstract>Abstract Objective To compare the efficacy of vaginal versus sublingual misoprostol for second-trimester pregnancy termination, and to evaluate the effect on the blood flow of the uterine and umbilical arteries. Methods Forty-nine patients were randomized to receive either 200 μg of vaginal misoprostol every 6 hours or 200 μg of misoprostol sublingually every 6 hours. Doppler velocimetry studies were assessed immediately before and 60 minutes after the administration of the first dose. Standard descriptive calculations, Mann–Whitney U, Wilcoxon, and χ2 tests were performed. Results The mean interval between induction and onset of active labor, induction and delivery, and the duration of oxytocin administration were significantly shorter in the sublingual misoprostol group. Both routes of administration increased the Doppler indices for the uterine arteries; however, misoprostol via the sublingual route did not affect the umbilical arteries. Conclusion Sublingual administration of misoprostol for second-trimester medical abortion results in a higher success rate and does not affect umbilical blood flow.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>19428005</pmid><doi>10.1016/j.ijgo.2009.04.001</doi><tpages>4</tpages></addata></record> |
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| ispartof | International journal of gynecology and obstetrics, 2009-09, Vol.106 (3), p.250-253 |
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| subjects | Abortifacient Agents, Nonsteroidal - administration & dosage Abortion, Induced - methods Administration, Intravaginal Administration, Sublingual Biological and medical sciences Birth control Blood Flow Velocity - drug effects Cardiovascular system Digestive system Doppler measurement Female Gynecology. Andrology. Obstetrics Humans Induced abortion. Therapeutic abortion Investigative techniques, diagnostic techniques (general aspects) Laser-Doppler Flowmetry Medical sciences Misoprostol - administration & dosage Obstetrics and Gynecology Pharmacology. Drug treatments Pregnancy Pregnancy Trimester, Second Regional Blood Flow - drug effects Second-trimester termination Sublingual misoprostol Treatment Outcome Ultrasonic investigative techniques Ultrasonography Umbilical Arteries - diagnostic imaging Umbilical Arteries - drug effects Uterus - blood supply Vaginal misoprostol |
| title | Vaginal versus sublingual misoprostol for second-trimester pregnancy termination and effect on Doppler measurements |
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