Differentiated implication of Lactobacillus GG and L. gasseri TMC0356 to immune responses of murine Peyer's patch

ABSTRACT Lactobacillus GG and L. gasseri TMC0356 were examined for their potential to alter the immune responses of murine PP cells in vitro and in vivo. Lactobacillus GG and L. gasseri TMC0356 characteristically stimulated the production of IL‐12, IL‐6, IFN‐γ and IgA from isolated PP cells in vitro...

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Published in:Microbiology and immunology 2009-08, Vol.53 (8), p.475-480
Main Authors: Harata, Gaku, He, Fang, Kawase, Manabu, Hosono, Akira, Takahashi, Kyoko, Kaminogawa, Shuichi
Format: Article
Language:English
Subjects:
Animals
Antibodies, Bacterial - blood
Cytokines - immunology
Female
immunoglobulin A
interleukin
Lactobacillus
Lactobacillus - immunology
Mice
Mice, Inbred BALB C
Peyer's patch
Peyer's Patches - cytology
Peyer's Patches - immunology
Peyer's Patches - microbiology
Probiotics - administration & dosage
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Summary:ABSTRACT Lactobacillus GG and L. gasseri TMC0356 were examined for their potential to alter the immune responses of murine PP cells in vitro and in vivo. Lactobacillus GG and L. gasseri TMC0356 characteristically stimulated the production of IL‐12, IL‐6, IFN‐γ and IgA from isolated PP cells in vitro. Anatomical analysis indicated uptake of these bacteria by the PP tissue after giving orally in mice. Isolated PP cells exposed to Lactobacillus GG in vivo secreted more IFN‐γ, IL‐6 and total IgA, whereas those exposed to L. gasseri TMC0356 in vivo did not exhibit altered immune responses in terms of cytokine and IgA production. Therefore, these two bacteria might exhibit different immunodulatory effects in host animals by strain‐dependent interaction with gut‐associated lymphoid tissues in vivo.
ISSN:0385-5600
1348-0421
DOI:10.1111/j.1348-0421.2009.00146.x