Microglial imaging with positron emission tomography and atrophy measurements with magnetic resonance imaging in multiple sclerosis: a correlative study

Objective: The objectives of the present study were to assess brain atrophy in multiple sclerosis (MS) patients during different disease stages and to investigate by PET and [11C]PK11195, a marker of microglial activation, the relationship between inflammation, atrophy and clinically relevant measur...

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Bibliographic Details
Published in:Multiple sclerosis 2005-04, Vol.11 (2), p.127-134
Main Authors: Versijpt, J, Debruyne, J C, Van Laere, K J, De Vos, F, Keppens, J, Strijckmans, K, Achten, E, Slegers, G, Dierckx, R A, Korf, J, De Reuck, J L
Format: Article
Language:English
Subjects:
Adult
Aged
Antineoplastic Agents - pharmacokinetics
Atrophy
Biological and medical sciences
Brain - pathology
Carbon Radioisotopes
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Female
Humans
Investigative techniques, diagnostic techniques (general aspects)
Isoquinolines - pharmacokinetics
Magnetic Resonance Imaging
Male
Medical sciences
Microglia - pathology
Middle Aged
Multiple Sclerosis - pathology
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Nervous system
Neurology
Positron-Emission Tomography - methods
Radiodiagnosis. Nmr imagery. Nmr spectrometry
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Summary:Objective: The objectives of the present study were to assess brain atrophy in multiple sclerosis (MS) patients during different disease stages and to investigate by PET and [11C]PK11195, a marker of microglial activation, the relationship between inflammation, atrophy and clinically relevant measures. Methods: Eight healthy subjects and 22 MS patients were included. Semiquantitative [11C]PK11195 uptake values, with normalization on cortical grey matter, were measured for magnetic resonance imaging T2- and T1-lesions and normal appearing white matter (NAWM). As atrophy index we used the ratio of the amount of white and grey matter divided by the ventricular size, using an optimized a priori based segmentation algorithm (SPM99). Results: Atrophy was significantly greater in MS patients compared to age-matched controls. A significant correlation was found between brain atrophy and both disease duration and disability, as measured with the Expanded Disability Status Scale. For NAWM, [11C]PK11195 uptake increased with the amount of atrophy, while T2-lesional [11C]PK11195 uptake values decreased according to increasing brain atrophy. Conclusions: The present study suggests that brain atrophy, correlating with disease duration and disability, is directly related to NAWM and T2-lesional inflammation as measured by microglial activation.
ISSN:1352-4585
1477-0970
DOI:10.1191/1352458505ms1140oa