Impaired gastric motor activity after abdominal surgery in rats

Postoperative ileus (POI) is a transient bowel dysmotility that occurs following abdominal surgery. Several mechanisms have been proposed such as neural reflex and inflammatory changes. We focused on gastric motility after abdominal surgery in rats. To investigate the time course of gastric motility...

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Bibliographic Details
Published in:Neurogastroenterology and motility 2005-04, Vol.17 (2), p.245-250
Main Authors: Fukuda, H., Tsuchida, D., Koda, K., Miyazaki, M., Pappas, T. N., Takahashi, T.
Format: Article
Language:English
Subjects:
Adrenergic Agents - pharmacology
Animals
celiac ganglionectomy
Digestive System Surgical Procedures - adverse effects
Eating
Ganglia, Sympathetic - surgery
Ganglionectomy
Gastrointestinal Motility - drug effects
Gastrointestinal Motility - physiology
guanethidine
Guanethidine - pharmacology
Ileus - etiology
Ileus - physiopathology
intestinal manipulation
Male
Postoperative Complications - physiopathology
Rats
Stomach - drug effects
Stomach - physiology
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Summary:Postoperative ileus (POI) is a transient bowel dysmotility that occurs following abdominal surgery. Several mechanisms have been proposed such as neural reflex and inflammatory changes. We focused on gastric motility after abdominal surgery in rats. To investigate the time course of gastric motility after surgery, gastric motility was continuously recorded before, during and after surgery. After laparotomy, terminal ileum was manipulated for 10 min. Gastric motility was recorded by a strain gauge transducer implanted on the serosal surface of the stomach. To investigate whether peripheral sympathetic nerve is involved in the pathogenesis of POI, effects of guanethidine and celiac ganglionectomy were tested on the postoperative gastric motility. Although isoflurane anaesthesia reduced the gastric motility to 40%, the motility recovered immediately when isoflurane was withdrawn. Intestinal manipulation reduced the postoperative gastric motility for 3–24 h after surgery, compared with preoperative levels. Guanethidine administration and celiac ganglionectomy restored the impaired gastric motility. Feeding increased the gastric motility in each group. It is suggested that the pathogenesis of postoperative gastric ileus induced by intestinal manipulation involves viscero‐sympathetic pathways. Intestinal manipulation causes impaired gastric motility via inhibitory sympathetic efferent pathway. Feeding may improve the postoperative gastric motility.
ISSN:1350-1925
1365-2982
DOI:10.1111/j.1365-2982.2004.00602.x