Long lasting immunity in chickens induced by a single shot of influenza vaccine prepared from inactivated non-pathogenic H5N1 virus particles against challenge with a highly pathogenic avian influenza virus

Abstract An influenza vaccine was prepared from inactivated whole particles of the non-pathogenic strain A/duck/Hokkaido/Vac-1/04 (H5N1) virus using an oil adjuvant containing anhydromannitol-octadecenoate-ether (AMOE). The vaccine was injected intramuscularly into five 4-week-old chickens, and 138...

Full description

Saved in:
Bibliographic Details
Published in:Vaccine 2009-08, Vol.27 (38), p.5174-5177
Main Authors: Sasaki, Takashi, Kokumai, Norihide, Ohgitani, Toshiaki, Sakamoto, Ryuichi, Takikawa, Noriyasu, Lin, Zhifeng, Okamatsu, Masatoshi, Sakoda, Yoshihiro, Kida, Hiroshi
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic
Allergy and Immunology
Animal vaccines
Animals
Antibodies, Viral - blood
Antigens
Applied microbiology
Atoms & subatomic particles
Avian influenza vaccine
Biological and medical sciences
Chickens - immunology
Chickens - virology
Fundamental and applied biological sciences. Psychology
H5 virus
Hemagglutination Inhibition Tests - veterinary
Influenza A Virus, H5N1 Subtype - immunology
Influenza A Virus, H5N1 Subtype - pathogenicity
Influenza in Birds - immunology
Influenza in Birds - prevention & control
Influenza Vaccines - immunology
Lasting protective immunity
Microbiology
Miscellaneous
Poultry
Reassortant Viruses - immunology
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Veterinary medicine
Virology
Viruses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract An influenza vaccine was prepared from inactivated whole particles of the non-pathogenic strain A/duck/Hokkaido/Vac-1/04 (H5N1) virus using an oil adjuvant containing anhydromannitol-octadecenoate-ether (AMOE). The vaccine was injected intramuscularly into five 4-week-old chickens, and 138 weeks after vaccination, they were challenged intranasally with 100 times 50% chicken lethal dose of the highly pathogenic avian influenza (HPAI) virus A/chicken/Yamaguchi/7/04 (H5N1). All 5 chickens survived without exhibiting clinical signs of influenza, although 2 days post-challenge, 3 vaccinated chickens shed limited titres of viruses in laryngopharyngeal swabs.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2009.06.070