Prepulse inhibition of startle and its moderation by schizotypy and smoking

The influences of smoking status and schizotypy on prepulse inhibition (PPI) of the startle eyeblink response were assessed in 71 healthy volunteers, across a wide range of prepulse‐to‐pulse intervals (50–2020 ms). Multiple regression analyses revealed that nonsmoking participants high in cognitive...

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Bibliographic Details
Published in:Psychophysiology 2005-03, Vol.42 (2), p.223-231
Main Authors: Evans, Lisa H., Gray, Nicola S., Snowden, Robert J.
Format: Article
Language:English
Subjects:
Acoustic Stimulation
Adolescent
Adult
Adult and adolescent clinical studies
Biological and medical sciences
Blinking - physiology
Female
Humans
Male
Medical sciences
Prepulse inhibition
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Reflex, Startle - physiology
Schizophrenia
Schizotypal Personality Disorder - physiopathology
Schizotypal Personality Disorder - psychology
Schizotypy
Sensorimotor gating
Smoking
Smoking - psychology
Startle
Surveys and Questionnaires
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Summary:The influences of smoking status and schizotypy on prepulse inhibition (PPI) of the startle eyeblink response were assessed in 71 healthy volunteers, across a wide range of prepulse‐to‐pulse intervals (50–2020 ms). Multiple regression analyses revealed that nonsmoking participants high in cognitive disorganization showed reduced PPI between 50 and 260 ms, whereas at prepulse intervals of 80 and 140 ms individuals high in introvertive anhedonia had greater PPI compared to their low‐scoring counterparts. Moreover, there were positive associations in nonsmokers between introvertive anhedonia and latencies to onset and peak response. In contrast, for those individuals who smoked these associations were attenuated or abolished. The results suggest that PPI is altered differentially in psychosis‐prone populations who display different symptom profiles, and that these relationships are moderated by smoking status.
ISSN:0048-5772
1540-5958
1469-8986
DOI:10.1111/j.1469-8986.2005.00280.x