CD19 function in central and peripheral B-cell development

Although the B-cell antigen receptor (BCR) factors most prominently in the maintenance and differentiation of mature B cells, it is now appreciated that co-receptor molecules can positively or negatively modulate signals through the BCR. Co-receptors are functionally defined as modifiers of BCR enga...

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Bibliographic Details
Published in:Immunologic research 2005-01, Vol.31 (2), p.119-132
Main Authors: Del Nagro, Christopher J, Otero, Dennis C, Anzelon, Amy N, Omori, Sidne A, Kolla, Ravi V, Rickert, Robert C
Format: Article
Language:English
Subjects:
Animals
Antigens, CD19 - physiology
B-Lymphocyte Subsets - cytology
B-Lymphocyte Subsets - immunology
B-Lymphocyte Subsets - metabolism
Cell Differentiation - immunology
Cell Differentiation - physiology
Humans
Receptors, Antigen, B-Cell - physiology
Signal Transduction - physiology
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Summary:Although the B-cell antigen receptor (BCR) factors most prominently in the maintenance and differentiation of mature B cells, it is now appreciated that co-receptor molecules can positively or negatively modulate signals through the BCR. Co-receptors are functionally defined as modifiers of BCR engagement and signal transduction, and are distinct from other accessory molecules that act independently to regulate B-cell growth. The co-receptor CD19 functions to augment signals by the pre-BCR/BCR and in doing so can modulate B-cell fate decisions at multiple stages of development. In mature B cells, CD19 also associates with complement receptor 2 (CR2/CD21) and is pivotal for transducing signals induced by co-recognition of complement C3d-fixed antigens by the BCR and CD21. In this article, we focus on recent progress in the understanding of CD19 function through the characterization of mouse models that relate in vivo function to biochemical properties of CD19.
ISSN:0257-277X
1559-0755
0257-277X
DOI:10.1385/IR:31:2:119