Value of Candida serum markers in patients with invasive candidiasis after myeloablative chemotherapy

Abstract Invasive Candida infections are associated with a significant morbidity and mortality. Detection of circulating biomarkers has been shown to precede conventional diagnostic methods, which is important in improving outcome. We investigated the performance of multiple biomarkers using Candida...

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Bibliographic Details
Published in:Diagnostic microbiology and infectious disease 2009-08, Vol.64 (4), p.408-415
Main Authors: Verduyn Lunel, Frans M, Mennink-Kersten, Monique A.S.H, Ruegebrink, Dorien, van der Lee, Henrich A.L, Donnelly, J. Peter, Blijlevens, Nicole M.A, Verweij, Paul E
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Antibodies, Fungal - blood
Antibody
Antigen
Antigens, Fungal - blood
beta-Glucans - blood
Biological and medical sciences
Biomarkers
Candida
Candida - isolation & purification
Candidiasis - diagnosis
Child
Child, Preschool
Female
Fundamental and applied biological sciences. Psychology
Hematology
Humans
Immunosuppressive Agents - adverse effects
Immunosuppressive Agents - therapeutic use
Infectious Disease
Infectious diseases
Internal Medicine
Male
Medical sciences
Microbiology
Middle Aged
Miscellaneous
Mycology
Myeloablative Agonists - adverse effects
Myeloablative Agonists - therapeutic use
Neutropenia
Young Adult
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Summary:Abstract Invasive Candida infections are associated with a significant morbidity and mortality. Detection of circulating biomarkers has been shown to precede conventional diagnostic methods, which is important in improving outcome. We investigated the performance of multiple biomarkers using Candida antigen and anti- Candida antibody detection systems of Platelia and Serion and β- d -glucan detection in serial serum samples from patients, treated for leukemia, with invasive candidiasis. The performance of single assays and combined detection appeared different for patients with 1 or more episodes of neutropenia and is therefore related to the phase of therapy for the underlying leukemia of the patient. These new insights may help to optimize the diagnostic strategies for the diagnosis of invasive candidiasis.
ISSN:0732-8893
1879-0070
DOI:10.1016/j.diagmicrobio.2009.04.012