Biomedical applications of distally controlled magnetic nanoparticles

Biomedical applications of distally controlled magnetic nanoparticles

Nano-sized magnetic particles are increasingly being used across a wide spectrum of biomedical fields. Upon functionalization to enable specific binding, magnetic particles and their targets can be conveniently positioned in vitro and in vivo by the distal application of magnetic fields. Furthermore...

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Bibliographic Details
Published in:Trends in biotechnology (Regular ed.) 2009-08, Vol.27 (8), p.468-476
Main Authors: Corchero, José Luis, Villaverde, Antonio
Format: Article
Language:eng
Subjects:
Atoms & subatomic particles
Biocompatibility
Biological activity
Biological and medical sciences
Biomedical Research - trends
Biomedical Technology - methods
Biotechnology
Drug dosages
Fundamental and applied biological sciences. Psychology
Health. Pharmaceutical industry
Humans
Industrial applications and implications. Economical aspects
Internal Medicine
Ligands
Magnetics
Membrane separation
Miscellaneous
Nanoparticles
Proteins
Tissue engineering
Toxicity
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Summary:Nano-sized magnetic particles are increasingly being used across a wide spectrum of biomedical fields. Upon functionalization to enable specific binding, magnetic particles and their targets can be conveniently positioned in vitro and in vivo by the distal application of magnetic fields. Furthermore, such particles can be magnetically heated after reaching their in vivo targets, thus inducing localized cell death that has a considerable therapeutic value in, for instance, cancer therapy. In this context, innovative biomedical research has produced novel applications that have exciting clinical potential. Such applications include magnetically enhanced transfection, magnetically assisted gene therapy, magnetically induced hyperthermia and magnetic-force-based tissue engineering, and the principles and utilities of these applications will be discussed here.
ISSN:0167-7799
1879-3096