Matrikines in the regulation of extracellular matrix degradation

The term “matrikines” was coined for designating peptides liberated by partial proteolysis of extracellular matrix macromolecules, which are able to regulate cell activities. Among these peptides, some of them may modulate proliferation, migration, protease production, or apoptosis. In this review,...

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Bibliographic Details
Published in:Biochimie 2005-03, Vol.87 (3), p.353-360
Main Authors: Maquart, F.X., Bellon, G., Pasco, S., Monboisse, J.C.
Format: Article
Language:English
Subjects:
Animals
Basement Membrane - metabolism
Collagen - metabolism
Elastin - metabolism
Enzyme Activation
Extracellular matrix
Extracellular Matrix - metabolism
Fibrinolysin - metabolism
Gene Expression Regulation, Enzymologic
Humans
Matrikine
Matrix metalloproteinases
Matrix Metalloproteinases - genetics
Matrix Metalloproteinases - metabolism
Models, Biological
Neoplasm Invasiveness - pathology
Peptide Hydrolases - metabolism
Peptides - metabolism
Plasmin
Proteases
Wound Healing - physiology
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Summary:The term “matrikines” was coined for designating peptides liberated by partial proteolysis of extracellular matrix macromolecules, which are able to regulate cell activities. Among these peptides, some of them may modulate proliferation, migration, protease production, or apoptosis. In this review, we summarize the activity of matrikines derived from elastin and interstitial or basement membrane collagens on the regulation of matrix metalloproteinases expression and/or activation, and on the plasminogen/plasmin system. Due to their activity, matrikines may play a significant role in physiological or pathological processes such as wound healing or tumor invasion.
ISSN:0300-9084
1638-6183
DOI:10.1016/j.biochi.2004.10.006