Network communications: lymphotoxins, LIGHT, and TNF

Lymphotoxins (LT) provide essential communication links between lymphocytes and the surrounding stromal and parenchymal cells and together with the two related cytokines, tumor necrosis factor (TNF) and LIGHT (LT-related inducible ligand that competes for glycoprotein D binding to herpesvirus entry...

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Bibliographic Details
Published in:Annual review of immunology 2005-01, Vol.23 (1), p.787-819
Main Author: Ware, Carl F
Format: Article
Language:English
Subjects:
Animals
Autoimmune Diseases - immunology
Herpesvirus
Humans
Lymphocytes - immunology
Lymphotoxin-alpha - immunology
Membrane Proteins - immunology
Mice
Models, Immunological
Signal Transduction
Tumor Necrosis Factor Ligand Superfamily Member 14
Tumor Necrosis Factor-alpha - immunology
Virus Diseases - immunology
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Summary:Lymphotoxins (LT) provide essential communication links between lymphocytes and the surrounding stromal and parenchymal cells and together with the two related cytokines, tumor necrosis factor (TNF) and LIGHT (LT-related inducible ligand that competes for glycoprotein D binding to herpesvirus entry mediator on T cells), form an integrated signaling network necessary for efficient innate and adaptive immune responses. Recent studies have identified signaling pathways that regulate several genes, including chemokines and interferons, which participate in the development and function of microenvironments in lymphoid tissue and host defense. Disruption of the LT/TNF/LIGHT network alleviates inflammation in certain autoimmune disease models, but decreases resistance to selected pathogens. Pharmacological disruption of this network in human autoimmune diseases such as rheumatoid arthritis alleviates inflammation in a significant number of patients, but not in other diseases, a finding that challenges our molecular paradigms of autoimmunity and perhaps will reveal novel roles for this network in pathogenesis.
ISSN:0732-0582
1545-3278
DOI:10.1146/annurev.immunol.23.021704.115719