High-grade and low-grade gliomas: differentiation by using perfusion MR imaging

Relative cerebral blood volume (rCBV) is a commonly used perfusion magnetic resonance imaging (MRI) technique for the evaluation of tumour grade. Relative cerebral blood flow (rCBF) has been less studied. The goal of our study was to determine the usefulness of these parameters in evaluating the his...

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Bibliographic Details
Published in:Clinical radiology 2005-04, Vol.60 (4), p.493-502
Main Authors: Hakyemez, B., Erdogan, C., Ercan, I., Ergin, N., Uysal, S., Atahan, S.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Astrocytoma - diagnosis
Astrocytoma - pathology
Biological and medical sciences
Blood flow
Blood Volume
Brain neoplasms
Brain Neoplasms - diagnosis
Brain Neoplasms - pathology
Cerebral blood vessels
Cerebrovascular Circulation
Contrast enhancement
Female
Flow dynamics
Glioblastoma - diagnosis
Glioblastoma - pathology
Glioma - diagnosis
Glioma - pathology
Humans
Image Enhancement - methods
Magnetic resonance (MR)
Magnetic Resonance Imaging - methods
Male
Medical sciences
Middle Aged
Neurology
Preoperative Care - methods
Prospective Studies
ROC Curve
Tumors of the nervous system. Phacomatoses
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Summary:Relative cerebral blood volume (rCBV) is a commonly used perfusion magnetic resonance imaging (MRI) technique for the evaluation of tumour grade. Relative cerebral blood flow (rCBF) has been less studied. The goal of our study was to determine the usefulness of these parameters in evaluating the histopathological grade of the cerebral gliomas. This study involved 33 patients (22 high-grade and 11 low-grade glioma cases). MRI was performed for all tumours by using a first-passage gadopentetate dimeglumine T2*-weighted gradient-echo single-shot echo-planar sequence followed by conventional MRI. The rCBV and rCBF were calculated by deconvolution of an arterial input function. The rCBV and rCBF ratios of the lesions were obtained by dividing the values obtained from the normal white matter of the contralateral hemisphere. For statistical analysis Mann–Whitney testing was carried out. A p value of less than 0.05 indicated a statistically significant difference. Receiver operating characteristic curve (ROC) analysis was performed to assess the relationship between the rCBV and rCBF ratios and grade of gliomas. Their cut-off value permitting discrimination was calculated. The correlation between rCBV and CBF ratios and glioma grade was assessed using Pearson correlation analysis. In high-grade gliomas, rCBV and rCBF ratios were measured as 6.50±4.29 and 3.32±1.87 (mean±SD), respectively. In low-grade gliomas, rCBV and rCBF ratios were 1.69±0.51 and 1.16±0.38, respectively. The rCBV and rCBF ratios for high-grade gliomas were statistically different from those of low-grade gliomas ( p0.05). The cut-off value was taken as 1.98 in the rCBV ratio and 1.25 in the rCBF ratio. There was a strong correlation between the rCBV and CBF ratios (Pearson correlation=0.830, p
ISSN:0009-9260
1365-229X
DOI:10.1016/j.crad.2004.09.009