Association analysis between schizophrenia and the AP-3 complex genes

A susceptibility gene for schizophrenia, dysbindin, is a component of BLOC-1, which interacts with the adaptor protein (AP)-3 complex. As a direct interaction between dysbindin and AP-3 complex was reported, we examined a possible association between 16 SNPs in the AP3 complex genes and schizophreni...

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Bibliographic Details
Published in:Neuroscience research 2009-09, Vol.65 (1), p.113-115
Main Authors: Hashimoto, Ryota, Ohi, Kazutaka, Okada, Takeya, Yasuda, Yuka, Yamamori, Hidenaga, Hori, Hiroaki, Hikita, Takao, Taya, Shinichiro, Saitoh, Osamu, Kosuga, Asako, Tatsumi, Masahiko, Kamijima, Kunitoshi, Kaibuchi, Kozo, Takeda, Masatoshi, Kunugi, Hiroshi
Format: Article
Language:English
Subjects:
Adaptor protein (AP)-3 complex
Adaptor Protein Complex 3 - genetics
Adaptor Protein Complex mu Subunits - genetics
Adult
AP3M1
Carrier Proteins - genetics
Dysbindin
Dystrophin-Associated Proteins
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Schizophrenia
Schizophrenia - genetics
Single nucleotide polymorphism
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Summary:A susceptibility gene for schizophrenia, dysbindin, is a component of BLOC-1, which interacts with the adaptor protein (AP)-3 complex. As a direct interaction between dysbindin and AP-3 complex was reported, we examined a possible association between 16 SNPs in the AP3 complex genes and schizophrenia using 432 cases and 656 controls. Nominal association between rs6688 in the AP3M1 gene and schizophrenia ( χ 2 = 6.33, P = 0.012, odds ratio = 0.80) was no longer positive after correction for multiple testing (corrected P = 0.192). The present results suggest that AP3 complex genes might not play a major role in the pathogenesis of schizophrenia in this population.
ISSN:0168-0102
1872-8111
DOI:10.1016/j.neures.2009.05.008