Peri‐operative oral triiodothyronine replacement therapy to prevent postoperative low triiodothyronine state following valvular heart surgery

Summary This study evaluated the effect of oral triiodothyronine (T3) replacement therapy, starting on the day of the surgery, on thyroid hormone concentrations and clinical outcome in high‐risk patients undergoing valvular heart surgery. Fifty patients were randomly allocated to either T3 or placeb...

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Bibliographic Details
Published in:Anaesthesia 2009-08, Vol.64 (8), p.871-877
Main Authors: Choi, Y. S., Kwak, Y. L., Kim, J. C., Chun, D. H., Hong, S. W., Shim, J. K.
Format: Article
Language:English
Subjects:
Administration, Oral
Adult
Aged
Anesthesia
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Anesthesiology
Biological and medical sciences
Cardiopulmonary Bypass
Critical Care - methods
Double-Blind Method
Drug Administration Schedule
Drug therapy
Euthyroid Sick Syndromes - etiology
Euthyroid Sick Syndromes - prevention & control
Female
Heart surgery
Heart Valves - surgery
Hemodynamics
Hormone Replacement Therapy - methods
Humans
Male
Medical sciences
Middle Aged
Perioperative Care - methods
Postoperative Complications - prevention & control
Postoperative period
Prospective Studies
Thyroid diseases
Thyroid Hormones - blood
Triiodothyronine - administration & dosage
Triiodothyronine - deficiency
Triiodothyronine - therapeutic use
Veins & arteries
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Summary:Summary This study evaluated the effect of oral triiodothyronine (T3) replacement therapy, starting on the day of the surgery, on thyroid hormone concentrations and clinical outcome in high‐risk patients undergoing valvular heart surgery. Fifty patients were randomly allocated to either T3 or placebo. In the treatment (T3) group patients received 20 μg of oral or nasogastric T3 every 12 h starting just before induction of anaesthesia and until the first day after surgery. T3 concentrations were significantly higher in the T3 group than the placebo group from 1 to 36 h after removal of the aortic cross clamp. The number of patients requiring vasopressin after discontinuing cardiopulmonary bypass was significantly greater in the placebo group than the T3 group. Significantly fewer patients required vasopressors in the T3 group on the first day after surgery.
ISSN:0003-2409
1365-2044
DOI:10.1111/j.1365-2044.2009.05984.x