Autoantibodies involved in neuropsychiatric manifestations associated with Systemic Lupus Erythematosus

Abstract In the course of Systemic Lupus Erythematosus (SLE), a variety of neuropsychiatric disturbances is reported with a prevalence ranging from 17% to 75%. The diagnosis of these syndromes is difficult and requires a careful psychiatric evaluation. Distinct autoantibodies detectable in serum or...

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Bibliographic Details
Published in:Journal of neuroimmunology 2009-07, Vol.212 (1), p.3-9
Main Authors: Colasanti, Tania, Delunardo, Federica, Margutti, Paola, Vacirca, Davide, Piro, Ettore, Siracusano, Alessandra, Ortona, Elena
Format: Article
Language:English
Subjects:
Allergy and Immunology
Antibodies, Anticardiolipin - physiology
Antibodies, Antinuclear - physiology
Autoantibodies
Autoantibodies - physiology
Endothelial Cells - immunology
Endothelium
Gangliosides - immunology
Glial Fibrillary Acidic Protein - immunology
Humans
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - psychology
Mental Disorders - etiology
Microtubule-Associated Proteins - immunology
Neurology
Neurons
Neurons - immunology
Neuropsychiatric manifestations
Pathogenesis
Phosphoric Monoester Hydrolases - immunology
Receptors, N-Methyl-D-Aspartate - immunology
Ribosomes - immunology
Systemic Lupus Erythematosus
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Description
Summary:Abstract In the course of Systemic Lupus Erythematosus (SLE), a variety of neuropsychiatric disturbances is reported with a prevalence ranging from 17% to 75%. The diagnosis of these syndromes is difficult and requires a careful psychiatric evaluation. Distinct autoantibodies detectable in serum or cerebrospinal fluid of patients with SLE are associated with the presence of neuropsychiatric disorders. These autoantibodies may have a pathogenic relevance in neuropsychiatric SLE or they may be merely an epiphenomenon. This review describes the various autoantibodies reported to be associated with neuropsychiatric manifestations in SLE and discusses their possible role.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2009.05.003