IL-10 and IL-27 producing dendritic cells capable of enhancing IL-10 production of T cells are induced in oral tolerance

Abstract Oral tolerance is a key feature of intestinal immunity, generating systemic tolerance to ingested antigens (Ag). Dendritic cells (DC) have been revealed as important immune regulators, however, the precise role of DC in oral tolerance induction remains unclear. We investigated the character...

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Bibliographic Details
Published in:Immunology letters 2009-06, Vol.125 (1), p.7-14
Main Authors: Shiokawa, Aya, Tanabe, Kosuke, Tsuji, Noriko M, Sato, Ryuichiro, Hachimura, Satoshi
Format: Article
Language:English
Subjects:
Administration, Oral
Allergy and Immunology
Animals
Dendritic cell
Dendritic Cells - immunology
Dendritic Cells - metabolism
DNA-Binding Proteins - genetics
DNA-Binding Proteins - immunology
DNA-Binding Proteins - metabolism
Forkhead Transcription Factors - immunology
Forkhead Transcription Factors - metabolism
IL-10
IL-27
Immune Tolerance - immunology
Interleukin-10 - immunology
Interleukin-10 - metabolism
Interleukins - immunology
Interleukins - metabolism
Lymph Nodes - immunology
Lymph Nodes - metabolism
Mice
Mice, Inbred BALB C
Mice, Knockout
Mice, Transgenic
Mouth - immunology
Oral tolerance
Ovalbumin - immunology
Peyer's Patches - immunology
Peyer's Patches - metabolism
Receptors, Antigen, T-Cell - immunology
Receptors, Antigen, T-Cell - metabolism
Spleen - immunology
Spleen - metabolism
T-Lymphocytes - immunology
T-Lymphocytes - metabolism
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Summary:Abstract Oral tolerance is a key feature of intestinal immunity, generating systemic tolerance to ingested antigens (Ag). Dendritic cells (DC) have been revealed as important immune regulators, however, the precise role of DC in oral tolerance induction remains unclear. We investigated the characteristics of DC in spleen, mesenteric lymph node (MLN), and Peyer's patch (PP) after oral Ag administration in a TCR-transgenic mouse model. DC from PP and MLN of tolerized mice induced IL-10 production but not Foxp3 expression in cocultured T cells. IL-10 production was markedly increased after 5–7-day Ag administration especially in PP DC. On the other hand, IL-27 production was increased after 2–5-day Ag administration. CD11b+ DC, which increased after ingestion of Ag, prominently expressed IL-10 and IL-27 compared with CD11b− DC. These results suggest that IL-10 and IL-27 producing DC are increased by interaction with antigen specific T cells in PP, and these DC act as an inducer of IL-10 producing T cells in oral tolerance.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2009.05.002