Long-term outcome of autoimmune pancreatitis

Purpose Autoimmune pancreatitis (AIP) is a unique form of pancreatitis and can be complicated with various extrapancreatic lesions. Little is known about the long-term clinical course of AIP. Here we aimed to document the clinical course of AIP. Methods For this study, we recruited 21 patients, aver...

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Bibliographic Details
Published in:Journal of gastroenterology 2009-07, Vol.44 (7), p.726-732
Main Authors: Uchida, Kazushige, Yazumi, Shujiro, Nishio, Akiyoshi, Kusuda, Takeo, Koyabu, Masaki, Fukata, Masanori, Miyoshi, Hideaki, Sakaguchi, Yutaku, Fukui, Toshiro, Matsushita, Mitsunobu, Takaoka, Makoto, Okazaki, Kazuichi
Format: Article
Language:English
Subjects:
Abdominal Surgery
Aged
Aged, 80 and over
Autoimmune Diseases - complications
Autoimmune Diseases - diagnosis
Autoimmune Diseases - drug therapy
Biliary Tract
Colorectal Surgery
Female
Gastroenterology
Hepatology
Humans
Male
Medicine
Medicine & Public Health
Methylprednisolone - therapeutic use
Middle Aged
Original Article—Liver
Pancreas
Pancreatitis - complications
Pancreatitis - diagnosis
Pancreatitis - immunology
Pancreatitis - pathology
Prognosis
Recurrence
Surgical Oncology
Trypsin - blood
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Summary:Purpose Autoimmune pancreatitis (AIP) is a unique form of pancreatitis and can be complicated with various extrapancreatic lesions. Little is known about the long-term clinical course of AIP. Here we aimed to document the clinical course of AIP. Methods For this study, we recruited 21 patients, averaging 66.5 years in age (range, 19-84 years) and observed them at a mean interval of 40.8 months (range, 18-130 months). Three of the patients were also diagnosed with retroperitoneal fibrosis, 3 had sialoadenitis, 2 had chronic thyroiditis, 1 had interstitial nephritis, and 1 had interstitial pneumonia. Three of the patients underwent surgical therapy, 12 patients received methylprednisolone (PSL) treatment, and the 6 remaining patients received no treatment. Results Enlargement of the pancreas was attenuated in all the PSL-treated patients. Seven of the 21 patients showed pancreatic atrophy, of whom 2 were non-PSL-treated patients. Three patients developed chronic pancreatitis. One patient was diagnosed with pancreatic cancer after 50 months of PSL therapy. Conclusions As with chronic pancreatitis patients, AIP patients should be observed closely for abnormality in pancreatic function.
ISSN:0944-1174
1435-5922
DOI:10.1007/s00535-009-0049-3