A randomized and blinded field trial to assess the efficacy of an autogenous vaccine to prevent naturally occurring infectious bovine keratoconjunctivis (IBK) in beef calves

Abstract A randomized and blinded 2-arm parallel trial was conducted to assess the efficacy of an autogenous vaccine to prevent naturally occurring infectious bovine keratoconjunctivis (IBK) in beef calves. The trial was managed between May and November 2008 on university owned farms in Iowa and Wis...

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Bibliographic Details
Published in:Vaccine 2009-07, Vol.27 (34), p.4585-4590
Main Authors: Funk, L, O’Connor, A.M, Maroney, M, Engelken, T, Cooper, V.L, Kinyon, J, Plummer, P
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Applied microbiology
Autogenous
Autovaccines - administration & dosage
Autovaccines - immunology
Bacterial Vaccines - administration & dosage
Bacterial Vaccines - immunology
Biological and medical sciences
Body Weight
Cattle
Cattle Diseases - immunology
Cattle Diseases - prevention & control
Colleges & universities
Fundamental and applied biological sciences. Psychology
Immunization
Immunization, Secondary - methods
Incidence
Infectious bovine kereatoconjunctivitis
Injections, Subcutaneous
Iowa
Keratoconjunctivitis, Infectious - immunology
Keratoconjunctivitis, Infectious - prevention & control
Laboratories
Microbiology
Moraxella
Moraxella - immunology
Ovis
Placebos - administration & dosage
Randomized clinical trial
Vaccine
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Wisconsin
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Summary:Abstract A randomized and blinded 2-arm parallel trial was conducted to assess the efficacy of an autogenous vaccine to prevent naturally occurring infectious bovine keratoconjunctivis (IBK) in beef calves. The trial was managed between May and November 2008 on university owned farms in Iowa and Wisconsin. The vaccine at Iowa contained Moraxella bovoculi ( M. bovoculi ) while the organism used in the Wisconsin herds vaccine was Branhemella ovis ( B. ovis renamed M. ovis ). Calves born between January and May 2008 without visible corneal lesions were randomized to receive an autogenous vaccine or placebo vaccine using a computer generated sequence. Two subcutaneous doses were administered 21–28 days apart. Allocation to treatment was concealed using bottles marked A or B. Staff were blind to the treatment allocation. The primary outcome was IBK cumulative incidence over the study period. The secondary outcome was weaning weight. Only the Iowa herd met the criteria for an “at-risk” herd i.e. >15% IBK in unvaccinated calves and M. bovoculi isolation from IBK cases. Analysis was “per-protocol”. The cumulative incidence of IBK was 47/105 in vaccinated calves and 49/109 in unvaccinated calves (unadjusted odds ratio = 0.99, 95% CI: 0.58–1.70). Weight at weaning did not differ between the vaccinated cohort 148 kg (SD: ±27) and unvaccinated cohort 146 kg (SD: ±26) (unadjusted β = 1.5 and 95% CI: −5.5 to 8.6). Results indicate that the autogenous vaccine was ineffective in this study population.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2009.05.082