Soluble E-selectin, leptin, triglycerides, and insulin resistance in nonobese Japanese type 2 diabetic patients

The aim of the present study was to investigate the relationships between insulin resistance and soluble E-selectin, body mass index (BMI), leptin, and serum lipid profile including triglycerides in nonobese Japanese type 2 diabetic patients. A total of 97 nonobese Japanese type 2 diabetic patients...

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Bibliographic Details
Published in:Metabolism, clinical and experimental clinical and experimental, 2005-03, Vol.54 (3), p.376-380
Main Authors: Taniguchi, Ataru, Fukushima, Mitsuo, Nakai, Yoshikatsu, Kuroe, Akira, Yamano, Gen, Yanagawa, Takiko, Ohgushi, Minako, Ohya, Michihiro, Yoshii, Satoru, Taki, Yoshiro, Seino, Yutaka
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Blood Pressure
Body Mass Index
Cholesterol - blood
Cholesterol, LDL - blood
Diabetes Mellitus, Type 2 - blood
Diabetes. Impaired glucose tolerance
E-Selectin - blood
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Glycated Hemoglobin A - analysis
Homeostasis
Humans
Insulin Resistance
Japan
Leptin - blood
Medical sciences
Middle Aged
Regression Analysis
Triglycerides - blood
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Summary:The aim of the present study was to investigate the relationships between insulin resistance and soluble E-selectin, body mass index (BMI), leptin, and serum lipid profile including triglycerides in nonobese Japanese type 2 diabetic patients. A total of 97 nonobese Japanese type 2 diabetic patients aged 43 to 84 years were examined. The duration of diabetes was 11.2 ± 0.8 years. In conjunction with BMI and fasting concentrations of plasma glucose, serum lipids (triglycerides, total cholesterol, and high-density lipoprotein cholesterol) and serum insulin, soluble E-selectin, and leptin were also measured. The low-density lipoprotein (LDL) cholesterol level was calculated using the Friedewald formula. Insulin resistance was estimated by the homeostasis model assessment. The subjects were divided into 2 groups according to the value of insulin resistance estimated by the homeostasis model assessment. Values greater than 2.5 were indicative of the insulin-resistant state, and values less than 2.5 were indicative of the insulin-sensitive state. The insulin-resistant group had significantly higher levels of E-selectin, leptin, triglycerides, total and LDL cholesterol, and diastolic blood pressure as compared with the insulin-sensitive group. There was, however, no significant difference in age, sex, diabetes duration, BMI, systolic blood pressure, HbA1c, and high-density lipoprotein cholesterol between the 2 groups. Univariate regression analysis showed that insulin resistance was positively correlated to E-selectin ( r = 0.305, P = .003), BMI ( r = 0.283, P = .006), leptin ( r = 0.296, P = .004), HbA1c ( r = 0.241, P = .018), serum triglycerides ( r = 0.385, P < .001), serum total ( r = 0.240, P = .019) and LDL cholesterol ( r = 0.254, P = .013) levels, and systolic ( r = 0.247, P = .024) and diastolic ( r = 0.305, P = .006) blood pressure. Multiple regression analyses showed that insulin resistance was independently predicted by serum E-selectin (F = 18.4), serum leptin (F = 14.0) and serum triglycerides (F = 20.0) levels, which explained 45.0% of the variability of insulin resistance. From these results, it can be concluded that in conjunction with serum triglycerides and serum leptin, serum E-selectin is another important independent factor associated with insulin resistance in nonobese Japanese type 2 diabetic patients.
ISSN:0026-0495
1532-8600
DOI:10.1016/j.metabol.2004.10.006