Contribution of left ventricular diastolic dysfunction to heart failure regardless of ejection fraction

Heart failure (HF) has been classified as systolic and diastolic based on the left ventricular ejection fraction. We hypothesized that left ventricular diastolic dysfunction is an important element of HF regardless of ejection fraction. Two hundred six patients who had clinical HF were compared with...

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Bibliographic Details
Published in:The American journal of cardiology 2005-03, Vol.95 (5), p.603-606
Main Authors: Brucks, Steffen, Little, William C., Chao, Tania, Kitzman, Dalane W., Wesley-Farrington, Deborah, Gandhi, Sanjay, Shihabi, Zakariya K.
Format: Article
Language:English
Subjects:
Aged
Analysis of Variance
Biological and medical sciences
Cardiology. Vascular system
Diastole - physiology
Echocardiography, Doppler
Female
Heart
Heart Failure - etiology
Heart Failure - physiopathology
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Humans
Male
Medical sciences
Middle Aged
Natriuretic Peptide, Brain - blood
Proportional Hazards Models
Regression Analysis
Stroke Volume
Survival Rate
Ventricular Dysfunction, Left - complications
Ventricular Dysfunction, Left - physiopathology
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Summary:Heart failure (HF) has been classified as systolic and diastolic based on the left ventricular ejection fraction. We hypothesized that left ventricular diastolic dysfunction is an important element of HF regardless of ejection fraction. Two hundred six patients who had clinical HF were compared with 72 age-matched controls. Diastolic dysfunction, as assessed by the mitral filling pattern and tissue Doppler imaging, was present in >90% of patients who had HF regardless of ejection fraction and was more frequent and severe than in age-matched controls (p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2004.11.006