Sustained Viral Suppression and Immune Recovery in HIV Type 1—Infected Children after 4 Years of Highly Active Antiretroviral Therapy

We report the data from a long-term study of 31 human immunodeficiency virus type 1 (HIV-1)—infected children who were treated with highly active antiretroviral therapy. A high proportion of the children had undetectable HIV-1 RNA levels. CD4+ T cell counts recovered and remained stable. Adverse eve...

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Bibliographic Details
Published in:Clinical infectious diseases 2005-02, Vol.40 (4), p.604-608
Main Authors: Fraaij, Pieter L. A., Verweel, Gwenda, van Rossum, Annemarie M. C., van Lochem, Ellen G., Schutten, Martin, Weemaes, Corry M. R., Hartwig, Nico G., Burger, David M., de Groot, Ronald
Format: Article
Language:English
Subjects:
Adolescent
AIDS
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiretroviral drugs
Antiretroviral Therapy, Highly Active - methods
Antiviral agents
Biological and medical sciences
CD4 Lymphocyte Count
Child
Child growth
Child, Preschool
Children
Children & youth
Cohort Studies
Drug therapy
Female
Highly active antiretroviral therapy
HIV
HIV 1
HIV Infections - drug therapy
HIV Infections - immunology
HIV Infections - virology
HIV-1 - drug effects
HIV/AIDS
Human immunodeficiency virus
Human viral diseases
Humans
Immune system
Infectious diseases
Male
Medical sciences
Pharmacology. Drug treatments
Prospective Studies
RNA
RNA, Viral - blood
Statistical median
T lymphocytes
Time Factors
Treatment Outcome
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Virology
Viruses
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Description
Summary:We report the data from a long-term study of 31 human immunodeficiency virus type 1 (HIV-1)—infected children who were treated with highly active antiretroviral therapy. A high proportion of the children had undetectable HIV-1 RNA levels. CD4+ T cell counts recovered and remained stable. Adverse events were observed frequently but were mostly mild.
ISSN:1058-4838
1537-6591
DOI:10.1086/427696