Adeno-associated virus and human papillomavirus types in cervical samples of pregnant and non-pregnant women

Abstract Objective To investigate the prevalence of AAV and HPV DNA and their types in cervical secretion from pregnant and non-pregnant women. Study design The samples were obtained from 40 pregnant and 62 non-pregnant women who were attended at the outpatient clinic of the Federal University Hospi...

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Bibliographic Details
Published in:European journal of obstetrics & gynecology and reproductive biology 2009-07, Vol.145 (1), p.41-44
Main Authors: Freitas, Luciana B, Pereira, Christiane C, Checon, Rita, Leite, José Paulo G, Nascimento, Jussara P, Spano, Liliana C
Format: Article
Language:English
Subjects:
Adeno-associated virus
Adult
Biological and medical sciences
Brazil
Cervical secretion
Cervix Uteri - virology
Cross-Sectional Studies
Dependovirus - classification
Dependovirus - genetics
Dependovirus - pathogenicity
DNA, Viral - analysis
Female
Gynecology. Andrology. Obstetrics
Helper Viruses - pathogenicity
Helper Viruses - physiology
Human papillomavirus types
Humans
Medical sciences
Obstetrics and Gynecology
Papillomaviridae - classification
Papillomaviridae - genetics
Papillomaviridae - pathogenicity
Papillomavirus Infections - diagnosis
Papillomavirus Infections - epidemiology
Parvoviridae Infections - diagnosis
Parvoviridae Infections - epidemiology
PCR
Pregnancy
Pregnancy Complications, Infectious - diagnosis
Pregnancy Complications, Infectious - epidemiology
Pregnant and non-pregnant women
Prevalence
Retrospective Studies
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Summary:Abstract Objective To investigate the prevalence of AAV and HPV DNA and their types in cervical secretion from pregnant and non-pregnant women. Study design The samples were obtained from 40 pregnant and 62 non-pregnant women who were attended at the outpatient clinic of the Federal University Hospital of Espírito Santo, Southeastern Brazil. AAV and HPV were investigated by PCR and typed by PCR and/or RFLP. Results The occurrence of AAV in all samples was 25.5% (26/102): 81% (21/26) and 19% (5/26) for AAV2/3 and AAV5 species, respectively. AAV were observed in 35% (14/40) and 19% (12/62) of pregnant and non-pregnant women, respectively. HPV occurred in 22% of all samples; 25% (10/40) in pregnant and 20% (12/60) in non-pregnant women. HPV types were determined for 72.7% of the strains, most of which classified as high-risk. AAV–HPV co-infection was observed in 15.4% (4/26), mostly in pregnant women. Conclusions There was a greater prevalence of AAV and HPV in pregnant than in non-pregnant women, which suggests that the gestational state may play a role in reactivating the viruses.
ISSN:0301-2115
1872-7654
DOI:10.1016/j.ejogrb.2009.03.024