Crystalloid deposits in the kidney

Light chain‐producing lymphoproliferative disorders such as multiple myeloma are frequently complicated by renal impairment. Typically, the renal biopsy of a patient with renal failure caused by multiple myeloma shows cast nephropathy, but occasionally crystals may be seen. We describe the case of a...

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Bibliographic Details
Published in:Nephrology (Carlton, Vic.) Vic.), 2005-02, Vol.10 (1), p.81-83
Main Authors: KELLER, LISA SUZANNE, FAULL, RANDALL JAMES, SMITH, PETER, SWIFT, JEFFREY, BANNISTER, KYM MALCOLM, OTTO, SOPHIE, PEH, CHEN AU
Format: Article
Language:English
Subjects:
Acute Kidney Injury - etiology
Acute Kidney Injury - pathology
Crystallization
crystalloid
Humans
Immunoglobulin Light Chains - chemistry
Kidney - pathology
Male
Middle Aged
multiple myeloma
Multiple Myeloma - complications
Multiple Myeloma - pathology
nephropathy
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Description
Summary:Light chain‐producing lymphoproliferative disorders such as multiple myeloma are frequently complicated by renal impairment. Typically, the renal biopsy of a patient with renal failure caused by multiple myeloma shows cast nephropathy, but occasionally crystals may be seen. We describe the case of a patient with acute renal failure caused by multiple myeloma in which, on renal and bone marrow biopsy, there were widespread crystalloid deposits. Crystalloid nephropathy is a very rare condition associated with multiple myeloma and other light chain‐secreting disorders. An underlying lymphoproliferative disorder should be considered in the differential diagnosis if crystalloid deposits are seen on a renal or other tissue biopsy.
ISSN:1320-5358
1440-1797
DOI:10.1111/j.1440-1797.2005.00290.x