Sweet Syndrome After Kidney Transplantation

Abstract The association between Sweet syndrome (acute febrile neutrophilic dermatosis) and malignancies, infection, and drugs has been well established, but the disorder has never been reported in a solid organ transplant recipient. We have presented the first reported case of Sweet syndrome connec...

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Bibliographic Details
Published in:Transplantation proceedings 2009-06, Vol.41 (5), p.1954-1956
Main Authors: Osband, A.J, Laskow, D.A, Mann, R.A, Berkowicz, T, Ianosi-Irimie, M, Boruchoff, S
Format: Article
Language:English
Subjects:
Adult
Arm - pathology
Biological and medical sciences
Biopsy
Dermatology
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Immunosuppressive Agents - therapeutic use
Kidney Failure, Chronic - surgery
Kidney Transplantation - adverse effects
Kidney Transplantation - immunology
Male
Medical sciences
Prednisone - therapeutic use
Skin involvement in other diseases. Miscellaneous. General aspects
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the urinary system
Sweet Syndrome - etiology
Sweet Syndrome - pathology
Tissue, organ and graft immunology
Treatment Failure
Treatment Outcome
Wound Healing
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Summary:Abstract The association between Sweet syndrome (acute febrile neutrophilic dermatosis) and malignancies, infection, and drugs has been well established, but the disorder has never been reported in a solid organ transplant recipient. We have presented the first reported case of Sweet syndrome connected with solid organ transplant. Our patient is a 38-year-old man who underwent deceased donor kidney transplant for focal and segmental glomerulosclerosis and after resuming dialysis 6 weeks posttransplant, was readmitted 2 months later with high fevers and multiple head, neck, chest, and back lesions. Cultures were negative, and skin biopsy was consistent with Sweet syndrome. The lesions responded to higher doses of prednisone. Sweet syndrome has been linked to multiple drugs and malignancies, but has also been linked with states of altered immunity. Posttransplant immunosuppression may be related to this occurrence.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2009.03.067