Regulation of Dendrite and Spine Morphogenesis and Plasticity by Catenins

The appropriate regulation of dendrite, spine, and synapse morphogenesis in neurons both during and after development is critical for the formation and maintenance of neural circuits. It is becomingly increasingly clear that the cadherin-catenin cell adhesion complex, a complex that has been widely...

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Bibliographic Details
Published in:Molecular neurobiology 2009-08, Vol.40 (1), p.46-54
Main Author: Arikkath, Jyothi
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Cadherins - metabolism
Catenins - physiology
Cell adhesion & migration
Cell Biology
Dendrites - metabolism
Humans
Morphogenesis
Nerve Net - embryology
Neurobiology
Neurology
Neuronal Plasticity
Neurons
Neurons - physiology
Neurosciences
Proteins
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Summary:The appropriate regulation of dendrite, spine, and synapse morphogenesis in neurons both during and after development is critical for the formation and maintenance of neural circuits. It is becomingly increasingly clear that the cadherin-catenin cell adhesion complex, a complex that has been widely studied in epithelia, regulates neuronal morphogenesis. More interestingly, the catenins, cytosolic proteins that bind to cadherins, regulate multiple aspects of neuronal morphogenesis including dendrite, spine, and synapse morphogenesis and plasticity, both independent of and dependent on their ability to bind cadherins. In this review, we examine some of the more recent and exciting studies that implicate individual catenins in various aspects of neuronal morphogenesis and plasticity.
ISSN:0893-7648
1559-1182
DOI:10.1007/s12035-009-8068-x