Tracking the re-emergence of epidemic chikungunya virus in Indonesia

Twenty-four distinct outbreaks of probable chikungunya (CHIK) etiology were identified throughout Indonesia from September 2001 to March 2003, after a near 20-year hiatus of epidemic CHIK activity in the country. Thirteen outbreak reports were based on clinical observations alone, and 11 confirmed b...

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Bibliographic Details
Published in:Transactions of the Royal Society of Tropical Medicine and Hygiene 2005-02, Vol.99 (2), p.128-141
Main Authors: Laras, Kanti, Sukri, Nono C., Larasati, Ria P., Bangs, Michael J., Kosim, Rizal, Djauzi, Wandra, Tony, Master, John, Kosasih, Herman, Hartati, Sri, Beckett, Charmagne, Sedyaningsih, Endang R., Beecham, H. James, Corwin, Andrew L.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Distribution
Aged
Aged, 80 and over
Alphavirus Infections - epidemiology
Alphavirus Infections - immunology
Antibodies, Viral - blood
Biological and medical sciences
Chikungunya virus
Chikungunya virus - immunology
Chikungunya virus - isolation & purification
Child
Child, Preschool
Disease Outbreaks
Epidemic
General aspects
Human infectious diseases. Experimental studies and models
Humans
Immunoglobulin G - blood
Immunoglobulin M - blood
Indonesia
Indonesia - epidemiology
Infectious diseases
Medical sciences
Middle Aged
Reverse Transcriptase Polymerase Chain Reaction - methods
Risk Factors
RNA, Viral - analysis
Seasons
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Summary:Twenty-four distinct outbreaks of probable chikungunya (CHIK) etiology were identified throughout Indonesia from September 2001 to March 2003, after a near 20-year hiatus of epidemic CHIK activity in the country. Thirteen outbreak reports were based on clinical observations alone, and 11 confirmed by serological/virological methods. Detailed epidemiological profiles of two investigated outbreaks in Bogor and Bekasi are presented. Human sera were screened using an ELISA for IgM and IgG anti-CHIK antibodies. Additionally, reverse transcriptase PCR and virus isolation were attempted for virus identification. The mean age of cases was 37 ± 18 years in Bogor and 33 ± 20 years in Bekasi. There was no outstanding case-clustering, although outbreak-affected households were observed to be geographically grouped within villages. The attack rates in Bogor and Bekasi were 2.8/1000 and 6.7/1000 inhabitants respectively. Both outbreaks started in the rainy season following increased Aedes aegypti and A. albopictus densities.
ISSN:0035-9203
1878-3503
DOI:10.1016/j.trstmh.2004.03.013