Effect of humulus lupulus on Gastric Secretion in a Rat Pylorus-Ligated Model

In this study, we investigated the pharmacological effect of humulus lupulus (hops) on gastric juice volume and acidity using a rat pylorus-ligated model. In an intraorally administered experiment, hops clearly increased gastric juice volume without affecting acidity. On the other hand, hops had no...

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Bibliographic Details
Published in:Biological & Pharmaceutical Bulletin 2005, Vol.28(2), pp.353-357
Main Authors: Kurasawa, Takashi, Chikaraishi, Yuichi, Naito, Akira, Toyoda, Yoshihiro, Notsu, Yoshitada
Format: Article
Language:eng ; jpn
Subjects:
acidity
Animals
carbachol
Gastric Juice - drug effects
Gastric Juice - metabolism
gastric juice volume
histamine
Humulus
humulus lupulus (hops)
Ligation
Male
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Pylorus - drug effects
Pylorus - metabolism
rat
Rats
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Summary:In this study, we investigated the pharmacological effect of humulus lupulus (hops) on gastric juice volume and acidity using a rat pylorus-ligated model. In an intraorally administered experiment, hops clearly increased gastric juice volume without affecting acidity. On the other hand, hops had no influence on gastric juice volume when it was intragastrically administered. A cholinergic agonist, carbachol, increased gastric juice volume without affecting acidity, whereas histamine increased gastric juice volume and acidity. The increase of gastric juice volume induced by carbachol was completely inhibited by atropine. On the other hand, atropine did not inhibit the increase in gastric juice volume induced by histamine. The increase in gastric juice volume induced by hops was completely inhibited by atropine. These results suggested that the increase in gastric juice volume induced by intraorally administered hops could be mediated by the cholinergic nervous system.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.28.353