Longitudinal study of serum carotenoid, retinol, and tocopherol concentrations in relation to breast cancer risk among postmenopausal women

Prospective studies have examined the association of serum and plasma carotenoids and micronutrients and breast cancer; however, to date, studies have only assessed exposure at one point in time. This study analyzed baseline and repeated serum measurements of carotenoids, retinol, and tocopherols to...

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Bibliographic Details
Published in:The American journal of clinical nutrition 2009-07, Vol.90 (1), p.162-169
Main Authors: Kabat, Geoffrey C, Kim, Mimi, Adams-Campbell, Lucile L, Caan, Bette J, Chlebowski, Rowan T, Neuhouser, Marian L, Shikany, James M, Rohan, Thomas E
Format: Article
Language:English
Subjects:
Adult
Antioxidants
beta Carotene - blood
Biological and medical sciences
blood composition
blood plasma
blood serum
Breast cancer
breast neoplasms
Breast Neoplasms - epidemiology
Breast Neoplasms - prevention & control
carotenoids
Carotenoids - blood
Clinical trials
diet-related diseases
elderly
Feeding. Feeding behavior
Female
Follow-Up Studies
Fundamental and applied biological sciences. Psychology
gamma-Tocopherol - blood
human nutrition
Humans
Incidence
Longitudinal Studies
Lycopene
mammary neoplasms (animal)
Menopause
Middle Aged
Multivariate Analysis
Postmenopause
quantitative analysis
risk assessment
Risk Factors
Studies
tocopherols
Tocopherols - blood
Vertebrates: anatomy and physiology, studies on body, several organs or systems
vitamin A
Vitamin A - blood
women
Women's Health Initiative
Womens health
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Summary:Prospective studies have examined the association of serum and plasma carotenoids and micronutrients and breast cancer; however, to date, studies have only assessed exposure at one point in time. This study analyzed baseline and repeated serum measurements of carotenoids, retinol, and tocopherols to assess their associations with postmenopausal breast cancer risk. Serum concentrations ofα-carotene,β-carotene,β-cryptoxanthin, lycopene, lutein + zeaxanthin, retinol,α-tocopherol, andγ-tocopherol were measured in a 6% sample of women in the Women’s Health Initiative clinical trials at baseline and at years 1, 3, and 6 and in a 1% sample of women in the observational study at baseline and at year 3. The association of baseline compounds and breast cancer risk was estimated by Cox proportional hazards models. In addition, repeated measurements were analyzed as time-dependent covariates. Of 5450 women with baseline measurements, 190 incident cases of breast cancer were ascertained over a median of 8.0 y of follow-up. After multivariable adjustment, risk of invasive breast cancer was inversely associated with baseline serumα-carotene concentrations (hazard ratio for highest compared with the lowest tertile: 0.55; 95% CI: 0.34, 0.90;P = 0.02) and positively associated with baseline lycopene (hazard ratio: 1.47; 95% CI: 0.98, 2.22;P = 0.06). Analysis of repeated measurements indicated thatα-carotene andβ-carotene were inversely associated with breast cancer and thatγ-tocopherol was associated with increased risk. The present study, which was the first to assess repeated measurements of serum carotenoids and micronutrients in relation to breast cancer, adds to the evidence of an inverse association of specific carotenoids with breast cancer. The positive associations observed for lycopene andγ-tocopherol require confirmation. This trial was registered at clinicaltrials.gov as NCT00000611.
ISSN:0002-9165
1938-3207
DOI:10.3945/ajcn.2009.27568