A novel antibiotic, linezolid, reduces intraperitoneal adhesion formation in the rat uterine horn model

Objective. To examine the effects of linezolid in prevention of adhesion formation in a rat uterine horn model. Design. Prospective randomized study. Setting. University Experimental Animal Research Laboratory Center. Sample. Ninety female Wistar albino rats. Methods. A dose response study was first...

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Bibliographic Details
Published in:Acta obstetricia et gynecologica Scandinavica 2009-01, Vol.88 (7), p.781-786
Main Authors: Aytan, Hakan, Caliskan, Ahmet C., Yener, Tamer, Demirturk, Fazli, Aytan, Pelin, Yenisehirli, Aydan
Format: Article
Language:English
Subjects:
Acetamides - administration & dosage
Acetamides - pharmacology
adhesion formation
Administration, Oral
Animals
Anti-Infective Agents - administration & dosage
Anti-Infective Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
dose response
Dose-Response Relationship, Drug
Female
Gynecology. Andrology. Obstetrics
Linezolid
Medical sciences
Oxazolidinones - administration & dosage
Oxazolidinones - pharmacology
Pharmacology. Drug treatments
Prospective Studies
Random Allocation
Rats
Rats, Wistar
Statistics, Nonparametric
Tissue Adhesions - pathology
Uterus - drug effects
Uterus - pathology
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Summary:Objective. To examine the effects of linezolid in prevention of adhesion formation in a rat uterine horn model. Design. Prospective randomized study. Setting. University Experimental Animal Research Laboratory Center. Sample. Ninety female Wistar albino rats. Methods. A dose response study was first conducted with 60 Wistar albino rats that were randomly assigned to six equal groups by administering vehicle (control), 5 mg/kg (Group 1), 15 mg/kg (Group 2), 50 mg/kg (Group 3), 100 mg/kg (Group 4), and 150 mg/kg (Group 5) linezolid starting three days before the adhesion inducing operation and continuing for 14 days postoperatively. Adhesion was scored clinically with a scoring system. The minimum effective dose was found to be 100 mg/kg/day. With this dose time response (starting three days before the operation and continuing for seven days), only preoperative and postoperative administration studies were conducted. Main outcome measures. Extent and severity of adhesions. Results. Total adhesion scores in the control and Groups 1 and 2 were significantly higher when compared with Groups 4 and 5, but not with Group 3. There were no significant differences in the adhesion scores between Groups 3, 4, and 5. In time response arm a total of 10 days treatment was not as effective as 17 days treatment. In postoperative and preoperative arms of the study, it was found that administration of linezolid only postoperatively or preoperatively did not affect adhesion formation significantly when compared with the control group. Conclusion. Linezolid was found to reduce intraperitoneal adhesion formation.
ISSN:0001-6349
1600-0412
DOI:10.1080/00016340903002873